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Semmelweis Pharmacology Semifinal Questions With Complete Solutions

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  • Microbiology Semmelweis
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  • Microbiology Semmelweis

Semmelweis Pharmacology Semifinal Questions With Complete Solutions H1R>>Gq>>increasing nasal/bronchial mucous secretion, increase NOS release, capillary permeability Bronchial SM contraction Suppresses AV node H2R>>Gs>>PKA>>increased Gastric acid secreation ...

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  • September 26, 2024
  • 46
  • 2024/2025
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  • Microbiology Semmelweis
  • Microbiology Semmelweis
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UpperClass
Semmelweis Pharmacology Semifinal
Questions With Complete Solutions

H1R>>Gq>>increasing nasal/bronchial mucous secretion,

increase NOS release,

capillary permeability

Bronchial SM contraction

Suppresses AV node




H2R>>Gs>>PKA>>increased Gastric acid secreation

stimulates B1 response, increased HR and contraction




Antagonist




1st Generation: are Lipophylic, allowing them to cross the BBB, thus can be used for allergic

reaction and motion sickness, and nausea and vomiting because they also block muscurinic

receptors. Also induce appetite increase (5HT blocker). Also antagonize alpha 1R thus induce

hypo tension. (cognitive impairment in elderly)

5. promethazine (alpha blockae and local anesthetic action)

6. diphenhydramine (OTC drug, most effective M blocker and sedator)

, Semmelweis Pharmacology Semifinal
Questions With Complete Solutions
9. dimetinden




2nd Generation: are less lypophylic, cannot cross the BB, so only used for allergic rhinitis with

minimal side effects.

7. (levo)cetirizine

8. (des)loratadine

10. fexofenadine




Systemic glucocorticoids (for Oral and Parenteral use) Glucocorticoids are anti-

inflammatives and immunosuppressives.




11. hydrocortizone -cortisol supplied as medication, short duration with gluco and

mineralcorticoid action

12. prednisolone - medium duration

13. methylprednisolone- antiinflam

15. triamcinolone - intermediate duration

14. dexamethasone -long duration (most potent) can be used in suppression tests, be observing

ACTH production if its via pituitary or ectopic production (fail)

, Semmelweis Pharmacology Semifinal
Questions With Complete Solutions

Mechanism:

-inhibit PLA2, so no Prostaglandins or leukotrienes

no COX2, PAF, IL2

-they decrease the expression of integrins and decrease capillary permeability, thus decreasing

leukocyte migration

-increase lysosomal membrane stability, thus decreasing phagocytosis




Side effects: can induce iatrogenic cushings syndrome by giving cortisol

-suppression of ACTH causes adrenal hypoplasia, so once the treatment stops there is no

endogenous cortisol left, resulting in shock, so the dose must be slowly decreased.

- hyperglycermia due to gluconeogenesis

-Gastric ulcers due to lack of PGE

- electrolyte imbalance due to increased aldosterone (mineralcorticoid action)

-decreased wound healing, increased infection (thrush, candida)




mineralocorticoid, local glucocorticoid, synthesis inhibitor 16. fludrocortizone


17. fluocinolon

, Semmelweis Pharmacology Semifinal
Questions With Complete Solutions
18. mometazone

19. budesonide

20. fluticazone

21. metyrapone




androgen 22. testosteron-undecanoat




antiandrogen 23. bicalutamide


24. finasteride




anabolic drug 25. nandrolon




cPDE-5 inhibior 28. sildenafil




estrogen and anti-estrogens Estrogens, synthetic estrogens have good oral bioavailability.


29. ethynylestradiol -steroidal estrogen

30. estradiol-natural estrogen (premann is natrual, taken from male urine)

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