KUBY IMMUNOLOGY 7TH EDITION BY OWEN TEST BANK CONTAINING QUESTIONS WITH CORRECT ANSWERS
3 views 0 purchase
Course
Course KUBY IMMUNOLOGY 7TH EDITION
Institution
Course KUBY IMMUNOLOGY 7TH EDITION
KUBY IMMUNOLOGY 7TH EDITION BY OWEN TEST BANK CONTAINING QUESTIONS WITH CORRECT ANSWERS
Four Types of Hypersensitivity Reactions - correct answers-Type I, Type II, Type III, & Type IV
Type I Hypersensitivity - correct answers-Allergy & Atopy (IgE)
Type II Hypersensitivity - correct answers-A...
KUBY IMMUNOLOGY 7TH EDITION BY OWEN
TEST BANK CONTAINING QUESTIONS WITH
CORRECT ANSWERS
Four Types of Hypersensitivity Reactions - correct answers-Type I, Type II, Type III, & Type IV
Type I Hypersensitivity - correct answers-Allergy & Atopy (IgE)
Type II Hypersensitivity - correct answers-Ab-mediated hypersensitivity (IgG & IgM)
Type III Hypersensitivity - correct answers-Immune complex-mediated hypersensitivity
(Immune-complexes)
Type IV - correct answers-Delayed Type Hypersensitivity (DTH) (T-Cells)
3 Mechanisms of Type II Hypersensitivity - correct answers-- Ab can activate complement ---
Mac
-Ab can mediate ADCC
- Ab can serve as Opsonin
Transfusion Reactions, Hemolytic diseases of the newborn, & Hemolytic Anemia (drug induced)
is what kind of Hypersensitivity Reaction? - correct answers-Type II Hypersensitivity Reaction
Concerning Hemolytic Disease of the Newborn, why is the first pregnancy not severely
affected? - correct answers-- Primary Response: IgM
- Secondary Response: IgG
What can induce Hemolytic Anemia? - correct answers-Drugs: Pennicillin, Streptomycin,
Ibuprofen, Naproxen.
- Drug gets absorbed into membrane proteins. Act as new Ag.
,What triggers a Type III Hypersensitivity Reaction? - correct answers-- Caused by large amounts
of immune complexes that arn't removed by normal mechanisms.
- Immune complexes = Ag+Ig (soluble)
Where can Type III Hypersensitivity Reactions occur? - correct answers-Depends on where the
Immune Complexes are Deposited.
- Near site of entry (localized)
- If it enters the blood (synovial membrane of joints, glomerular basement membrane, blood
vessel walls)
4 step mechanism of Type III Hypersensitivity Reactions - correct answers-1. Immune complex
activates complement
2. generate anaphylatoxins(C3a, C4a, C5a)
3. Recruits Neutrophils & granule release)
4. Anaphyltoxins cause mast cell degranulation
Arthus Reaction - correct answers-Localized Type III Hypersensitivity Reaction. Occurs when Ag
is applied subcutanously to an individual w/ high corresponding Ab.
Serum Sickness - correct answers-Late 19th Century- bacterial infections were treated by
injecting horse serum from horses immunized to a particular bacterial infection.
Farmers Lungs - correct answers-Type III Hypersensitivity Reaction that occurs when moldy hay
is inhaled.
Diseases resulting from Type III Hypersensitivity Reactions - correct answers-- Autoimmune
diseases
- systemic lupus erythematosus (SLE)
- Rheumatoid Artheritis
, - Multiple Sclerosis
- Hepatitis
4 step mechanism of a Type IV Hypersensitivity Reaction - correct answers-1. Th Cell encounters
Ag
2. Th Cell secrete cytokines that induced localized inflammatory reaction
3. Delayed-Type Hypersensitivity Reaction
4. Cytokines cause large influx of Mac's which cause tissue damage
Hallmarks of Type IV Hypersensitivity Reaction (DTH) - correct answers-- Delayed time for
reaction to develope (1-3 days)
- Purely cell-mediated rather than Ab-mediated
- Recruitment of Mac's (as opposed to neutrophils in type III Hypersensitivity reaction)
Primary & Secondary Ag exposure in DTH - correct answers-Primary- SENSITIZATION PHASE,
APC "sensitizes" the DTH-mediating cells which are typically Th1 cells
Secondary- Induces effector phase of DTH. Sensitized Th1 cells secrete cytokines & chemokines
to activate and recruit Macs.
Granuloma - correct answers-Walls off organism in the infected tissue. Macrophage lytic
enzymes damage the body tissue.
Test used to indicate prior exposure to M. tuberculosis - correct answers-Skin Test - PPD
(bacterial cell wall protein) is injected intradermally. Development of firm, red swollen site of
injection within ~48-72 hrs indicates positive test. (DTH)
Contact Dermatitis - correct answers-A Type IV Hypersensitivity Reaction- Occurs if a reactive
chemical compound binds to skin proteins. Modified proteins are then presented to T-cells.
- can be induced by pharmaceuticals, cosmetics, metal ions.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller viviengatwiri. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.49. You're not tied to anything after your purchase.
