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BMD225 BIOMEDICAL PHARMACOLOGY Pharmacokinetics questions with answers
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lOMoAR cPSD| 46870798BMD225 BIOMEDICAL PHARMACOLOGY Pharmacokinetics
questions with answers
Biomedical Pharmacology (BMD225)
, BMD225 BIOMEDICAL PHARMACOLOGY SEMESTER B 2022
PHARMACOKINETICS QUESTIONS
BACKGROUND FACTS
For the average 70 kg man, 60% of the total body weight is comprised of water, equaling 42L
Of the 42L of water found in the body, two-thirds of it is within the intracellular fluid (ICF) space, which equates
to 28L.
The ECFV is comprised of two spaces: The interstitial fluid volume (ISFV) and the plasma volume (PV). One-
third of the total body water is the ECFV, which is equivalent to 14L. Out of the extracellular fluid volume, 75%
or 10.5L of the volume is present in the interstitial space, and 25% of that water is in the plasma, which is
equivalent to 3.5L
In the figure above, the percentages are % of body weight.
FORMULAE:
These look like a lot, but many of them are derived from each other. Try to understand why they are the form
the are in (e.g. why increasing the t ½ is associated with a decreased clearance – it makes sense if you think
about it).
For many problems, you can use more than one of these formulae. So choose the one that is going to make
your calculation easiest.
For some problems, you have to combine two of the formulae, ie. Use one to work out a value that you need
for another formula.
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