NURS 660-EXAM 4 EXAM QUESTIONS CORRECT ANSWERS NEW UPDATE (VERIFIED A+ PASS)
Methadone is a _____ mu opioid receptor agonist. Side effects include _____ and _____ - Answers -Full. Constipation, sedation.
Buprenorphine (suboxone) is a _____ at the opioid receptor. Often combined with naltrexon...
NURS 660-EXAM 4 EXAM QUESTIONS
CORRECT ANSWERS NEW UPDATE
(VERIFIED A+ PASS)
Methadone is a _____ mu opioid receptor agonist. Side effects include _____ and
_____ - Answers -Full. Constipation, sedation.
Buprenorphine (suboxone) is a _____ at the opioid receptor. Often combined with
naltrexone to prevent abuse - Answers -Partial agonist
Naloxone (Narcan) is a mu receptor _____ . it has little effect compared to
buprenorphine (usually 1:4 ratio). - Answers -Antagonist
When buprenorphine/naloxone is injected or inhaled the ANTAGONIST effects of _____
dominate and w/d symptoms are precipitated - Answers -Naloxone
Overdose is much more likely with ____ than _____ - Answers -Methadone (full
agonist) > buprenorphine (partial agonist)
Extended-release buprenorphine can be dosed ____ - Answers -Subcutaneous once
per month after demonstrating tolerability for 1-week oral dosing
Naltrexone (ReVia) is a Mu receptor antagonist. Consideration before starting _____ -
Answers -Opiate free 7-10d or w/d symptoms
Naltrexone (ReVia) is available as once-monthly injection. How does it work? ____ -
Answers -Blocks Mu receptors to prevent euphoric effects if patient relapses. Helps with
abstinence to eliminate reward
3 meds FDA approved for AUD - Answers -Disufiram, Acamprosate, Naltrexone. Off-
label = Gabapentin and topiramate
NIAAA defines 'At risk' for men _____. Women _____. Above age 65 _____ - Answers -
Men= 4/day, 14/week. Women= 3/day, 7/week. >65= same as for women
Binge drinking for men _____, for women=_____ - Answers -Men= 5 in 2 hrs. Women=
4 in 2 hrs
Describe transmitters involved in etOH withdrawal - Answers -Over time alcoholics up-
regulate Glutamate to match the excess GABA. When there's a withdrawal there is a
relative excess
, Timeline of alcohol withdrawal - Answers -Minor- within 36 hrs. Seizures- 1-2d.
Hallucinosis- 1-2d. DT's- 1-4d
Disulfiram (Antabuse) adverse effects - Answers -Metallic taste, hepatotoxicity, optic
neuritis, peripheral neuropathy. (causes physically ill from buildup of acetaldehyde)
Acamprosate (Camral), how does it work? - Answers -Dosed 3x's/day. Cleared renally.
Glutamate receptor modulator.
How does naltrexone (ReVia) work in alcohol cessation. - Answers -Blocks opioid Mu
receptors and secondary dopamine (reduce pleasure and cravings)
Mild withdrawal starts within ____ hours and resolve in _____. These include: -
Answers -6-24. resolve 1-2 days. Tremor, anxiety, headache, insomnia, GI upset
Hallucinations start within _____ and resolve in _____ - Answers -12-24 hrs, resolve 1-
2days
Moderate and Severe withdrawal starts within _____ and lasts _____ - Answers -1-3
days, can last 5-7
DT's start _____ and can last _____ - Answers -3-4 days and last 2-3 days
Triad of Wernicke's - Answers -Encephalopathy, oculomotor dysfunction, gait ataxia
(often progresses to Korsakoff syndrome)
Opioid use disorder and neurotransmitter - Answers -Lowers NE and the brain up-
regulates to make more. When the opioid is removed there is a relative excess surge of
NE
Drug classes that help treat opioid w/d - Answers -Alpha 2 agonists (Clonidine,
Methyldopa, Tizanidine, Guanfacine), Beta blockers, SNRI
Impulsivity and reward= _____ striatum. Compulsivity and motor response inhibition=
_____ striatum - Answers -Ventral, dorsal
Reward pathway: mesolimbic from the _____ to the _____ - Answers -VTA to the
Nucleus accumbens (specifically in regards to dopamine)
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