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SCNM Pharm Exam Latest Update
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SCNM Pharm ExamLatest Update
This is the Drug of choice for TB. it works by inhibiting synthesis of lipids or nucleic
acids - Answer isoniazid
(Note- Toxicity/SE: Rash, fever, jaundice and peripheral neuritis, phenytoin, age-related
hepatic dysfunction)
This drug inhibits RNA polymerase of mycobacteria
and has side effects of Orange-red urine, feces, saliva, tears, sweat; Rash, fever,
Nausea and vomiting, Jaundice and hepatitis - Answer rifampin
This synthetic antibiotic inhibits protein synthesis and is indicated the treatment of
serious infections that are highly resistant (e.g MRSA) - Answer linezolide
This antibacterial drug used to treat leprosy and some kinds of skin diseases - Answer
Dapsone (it is a Sulfone, SE: hemolysis)
This oral or topical antifungal is for GI/skin Tyeast only. - Answer Nystatin
(SE: GI Sx and rash, hypersensitivity rare, not absorbed, so more GI effects)
Broad spectrum antifungal (systemic) that can cause Side effects involving GI, CNS,
rash, hepatotoxicity, significant drug interactions, N/V up to 10%, decrease
testosterone, gynecomastia, alopecia, menstrual irreg, at high doses decrease cortisol
synthesis. - Answer Ketoconazole
(CI: with antacids/cimetidine, fatal terfenadine/coumadin interaction)
This antifungal is for is the Chronic use in HIV for coccidiomycosis, candidiasis and
other fungi - Answer Fluconazole
(CI: renal dysfunction, reactions with warfarin and more
SE: GI, CNS, rash, hepatotoxicity, significant drug interactions)
This is an Antiparasitic (OK in pediact use), for recurrent non-gonococcal urethritis
trepomoniasis, trichomoniasis, bacterial vaginosis.
C/I in first trimester
DOC in giardia - Answer Metronidazole
,(SE: HA, nausea, dysgeusia)
This an antihelminthic drug for worms - Answer Albendazole
note: pediatric use OK
Acycovir - Treat? MOA? SE? - Answer HSV, Shingles treatment
guanine analog
SE: NVD, Myalgia
What drug is a produg to acyclovir? What does it Treat? SE? - Answer Valacyclovir, to
HSV
SE: HA, nausea, abdominal pain, dysmenorrhea, depression
Adefovir - Treats? SE? - Answer Anti-hepatitis B
Few SE: HA, rash, GI upset, increased LFT, possible nephrotoxicity
This is a cytidine nucleoside analog that treats Hep B? - Answer Lamivudine
effective in combination with zidovudine in treating AIDS and HIV
Inhibits HIV RevTrans and HB DNA polymerase
What anti-viral is used to treat hep B and many other DNA/RNA viruses, but is
Pregnancy X? What are its other SE? - Answer Ribavirin (interfeuron-alpha)
SE: CNS, GI, fever, dermatologic, flu-like sx
CI pregnancy for 6 months post-treatment
Note: also used to treat HBV + HCV
These drugs treat viral influenza - Answer Amantadine, rimantadine, oseltamavir,
zanamavir
These drugs are antiviral and antiparkinson's agents. Treats? SE? - Answer Influenza A
only
SE: CNS (drowsiness, HA, dizziness, insomnia), GI (ANV, dry mouth, constipation),
Anti-muscarinic (urinary retention, orthostasis), renal toxic
NOTE: Rimantadine has less SE as amantadine
What oral treatments of influenza inhibits neuraminidase and thus assembly/release of
virions? Treats? SE? - Answer Oseltamavir & Zanamavir
Tx: Swine/avian flu, Influenza A & B
, SE: insomnia, vertigo, NV (Zanamavir has respiratory sx because it is inhaled)
Protease Inhibitors treat HIV. What are their Side effects? - Answer Note: they are BAD
so start low dose and titrate up
GI upset, parathesia, rash, hyperglycemia endocrine/liver/lipid abnormalities
What is an over-the-counter topical cream for herpes that blocks viral entry if used
within 12hours of onset? - Answer Docosanol
What is a topical gel applied to HPV warts? - Answer podofilox
What is Ritonavir? - Answer a protease inhibitor (trade name Norvir) used in treating HIV
NRTI definition - Answer Nucleoside-analog Reverse-transcriptase inhibitors (NRTIs)
are a class of antiretroviral drug used to treat HIV infection. NRTIs inhibit activity of
reverse transcriptase, a viral DNA polymerase enzyme that retroviruses need to
reproduce.
What is Zidovudine? - Answer an NRTI for the treatment of AIDS
This NRTI has especially significant hypersensitivites. What are the signs of it? - Answer
Abacavir
E.g. Fever, Nausea vomiting, diarrhea, abdominal paoin, severe tiredness, achiness,
sore throat, SOB, cough
carry with patient
What are NNRTIs? What drugs are these? - Answer non-nucleoside reverse
transcriptase inhibitor
Nevirapine (Delavirdine -- don't have to know), Efavirenz
Side effects of NNRTIs? - Answer (Nevirapine & Efavirenz) Rash, HA, GI upset, CNS
(dysphoria, nightmares, dizziness, psychosis)
Mitochondrial toxicity
note, these tend to diminish after 8 weeks
This is an Anti-HIV drug that binds viral envelope to prevent fusion of cell with viral
membrane. What is its serious side effect? - Answer Enfurvirtide
Nephrolithiasis (drink >1.5L/day) (dry skin, hair loss, taste changes)
What drug is highly teratogenic used in erythema nodosum leprosum? - Answer
Thalidomide
This antibiotic is used to treat sensitive gram positive microbes - Answer Penicillin (G &
V,works by blocking Penicillin binding protein transpeptidase)
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