Humoral immunity - ANSWERSCARRIED OUT BY SOLUBLE PROTEINS (ANTIBODIES) WHICH ARE SECRETED
BY BONE MARROW - DERIVED WHITE BLOOD CELLS - B CELLS (B LYMPHOCYTES).
Cellular immunity - ANSWERSCARRIED OUT PRIMARILY (BUT NOT EXCLUSIVELY) BY THYMUS-DERIVED
LYMPHOCYTES (T CELLS) WHICH CIRCULATE IN BLOOD AND LYMPH AND RECOGNIZE SELF CELLS WHICH
WERE INFECTED OR TRANSFORMED.
Antigens on molecular level - ANSWERS-The recognition of foreign entities must involve
-the recognition of some molecules on their surface
, Good antigens - ANSWERS-large size
-complexity
-some structural stability
-degradability
-foreignness
Proteins - ANSWERSARE PRESENT ON THE SURFACES OF INVADING MICROORGANISMS AND THUS ARE
IMPORTANT TARGETS FOR THE IMMUNE SYSTEM
Searching for antibody molecule in serum - ANSWERS1)retained in 50% (NH4)2SO4 globulin fractions
2)in γ-globulin fractions
Papain digestion - ANSWERSTakes the antibody apart
Fragment antigen binding (Fab) - ANSWERSVariable
Fc - ANSWERSFragment crystalline
IgG - ANSWERS-(Fab)2Fc
-has -S-S- bridges
-has 2 heavy chains and 2 light chains
-M.W. 150,000 (7S)
-basic 4-chain structure
-a few subclasses
-major class in secondary immune response
-crosses placenta to protect fetus
IgM - ANSWERS-usually most common except in humans
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