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Naplex things to remember /good scores is guaranteed (new version ) Liver Lab Values - CORRECT ANSWERS -Acute liver toxicity, including from drugs = ↑ AST/ALT Chronic liver disease (cirrhosis) = ↑ AST/ALT, Alk Phos, total bilirubin, LDH, PT/INR ↓ albumin Alcoholic liver disease = ↑ AS...

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  • September 30, 2024
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  • 2024/2025
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  • Naplex things to remember
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gideonngari
Naplex things to remember /good scores is guaranteed
(new version 2024-2025)
Liver Lab Values - CORRECT ANSWERS -Acute liver toxicity, including from drugs = ↑
AST/ALT
Chronic liver disease (cirrhosis) = ↑ AST/ALT, Alk Phos, total bilirubin, LDH, PT/INR ↓
albumin
Alcoholic liver disease = ↑ AST > ALT (AST will be about double ALT), ↑ gamma
glutamyl transpeptidase (GGT)
Hepatic encephalopathy = ↑ Ammonia
Jaundice = ↑ total bilirubin

Portal HTN and variceal bleeding tx - CORRECT ANSWERS -- Octreotide (Sandostatin)
- Selective
- Vasopressin - non-selective
- Non selective BB: Nadolol & Propranolol (target HR 55-60 bpm)

Hepatic encephalopathy tx - CORRECT ANSWERS -Limit ammonia intake from food
(animal protien)
Lactulose = 1st line for both acute and chronic prevention therapy
Rifaxamin = 2nd line

Liver Drug interactions - CORRECT ANSWERS -ALL: CYP3A4 inducers, amiodarone
(bradycardia)
Sofosbuvir containing: antacids, PPI, H2RA
Technivie & Viekira Pak: estradiol containing, lovastatin & simvastatin

Hep B Lab Values - CORRECT ANSWERS -HBsAg + = infected by Hep B in blood &
can spread
HBsAb + = has antibodies from Hep B vaccine
HBcAb + = has antibodies from past or current infection

PAH drug treatment - CORRECT ANSWERS -Vasoreactivity test:
responder = oral CCB (NDA) - nifedipine, diltiazem, amlodipine
non responder = Potent vasodilators:
- Prostacyclin analogues and receptor agonists (IV epoprostenol [Flolan, Veletri],
Treprostinil [Remodulin])
- endothelin receptor antagonists (ERA - end in entan) (Bosenten, Ambrisentran,
Macitentan = teratogenic & hepatotoxic )
- PDE-5 inhibitors (revatio, adcirca)
- soluble guanylate cycle stimulator (Riociguat = teratogenic)

Asthma severity based on SABA use - CORRECT ANSWERS -INTERMITTENT: < 2
days/ week
PERSISTANT MILD: > 2 days/week but NOT daily

,OR > 1x/day
PERSISTANT MODERATE: daily
PERSISTANT SEVERE: Several times a day

HOW TO USE INHALERS - CORRECT ANSWERS -RESPIMAT products (MDI): TOP -
turn, open, press
Tiotropium - spiriva handihaler (DPI) = press once, bring to mouth horizonallty. inhale
TWICE
Aclidinium (Tudorza Pressair) - turns from red to green when ready. then green to red
after dose complete

smoking cessation 5 A's - CORRECT ANSWERS -ASK about tobacco use
ADVISE to quit
ASSESS willingness to make a quit attempt
ASSIST in quit attempt
ARRANGE follow up

smoking cessation treatment considerations - CORRECT ANSWERS -weight gain:
USE: Gum, lozenge, and bupropion SR (delay weight gain)
depression: USE: Bupropion SR
dentures: AVOID:Gum
Asthma/COPD: AVOID: Inhaler or spray
skin conditions: AVOID: Patch
seizures: AVOID: Bupropion SR, Varenicline
cost: AVOID: Inhaler, spray, bupropion SR, varenicline (rx drugs)

MAOi - 2 week washout period most drugs, 5 weeks Fluoxetine - CORRECT
ANSWERS -Isocarboxazid (Marplan)
Phenelzine (Nardil)
Tranylcypromine (Parnate)
Selegiline (transdermal patch) (MAO-B selective)
Zelapar

CYP INHIBITORS - CORRECT ANSWERS -**G PACMAN**
Grapefruit
Protease inhibitors (Ritonavir)
Azole antifungals
C - cyclosporine, cimetidine, cobicistat
Macrolides (NOT azithromycin)
Amiodarone (and dronedarone)
Non-DHP CCBs

CYP INDUCERS - CORRECT ANSWERS -**PS PORCS**
Phenytoin
Smoking
Phenobarbital

,Oxcarbazepine (and eslicarbazepine)
Rifampin
Carbamazepine (also auto-inducer)
St. Johns wort

Digoxin Levels - CORRECT ANSWERS -0.8-2 (Afib)
0.5-0.9 (HF)
Toxicity:
Initial s/sx: N/V, loss of appetite, bradycardia
Severe s/sx: blurred/double vision, greenish-yellow halos

FDA Orange Book - CORRECT ANSWERS -List approved drugs that can be
interchanged with generics based on therapeutic equivalence

CDC Pink Book - CORRECT ANSWERS -Info on epidemiology and vaccine
preventable diseases

Pink SHEET - CORRECT ANSWERS -News reports on regulatory, legislative, legal and
business developments

FDA Purple Book - CORRECT ANSWERS -List of biological drug products, including
biosimilars

RED BOOK (Pharmacy) - CORRECT ANSWERS -drug pricing

Red Book (pedes) - CORRECT ANSWERS -Summaries of pediatric infectious
diseases, abx treatment and vaccines

CDC Yellow Book - CORRECT ANSWERS -Info on the health risk of international
travel, required vaccines and prophylaxis meds

FDA Green Book - CORRECT ANSWERS -Info on approved animal drug products

Drugs that require PCV containers - CORRECT ANSWERS -**Leach Absorbs To Take
In Nutrients**
Lorazepam
Amiodarone
Tacrolimus
Taxanes
Insulin
Nitroglycerin

Drugs with FILTER requirements - CORRECT ANSWERS -my ***GAL, PLAT*** needs
a filter
Golimumab (simponi)
Amiodarone

, Lorazepam

Phenytoin
Lipids - 1.2 micron
Amphotericin B (lipid formualtions)
Taxanes (except docetaxel)

PROTECT FROM LIGHT - CORRECT ANSWERS -**Protect Every Necessary Med
from Daylight**
Phytonadione (Vit K, Mephyton)
Epoprogestenol
Nitroprusside
Micafungin
Doxycycline

SALINE ONLY - CORRECT ANSWERS -**A DIAbetic Can't Eat Pie**
Ampicillin
Daptomycin
Infliximab
Ampicillin/Sulbactam
Caspofungin
Ertapenem
Phenytoin

DEXTROSE ONLY - CORRECT ANSWERS -***BOAS like dextrose***
Bactrim
Oxaliplatin
Amphotericin B
Synercid (Quinupristin/Dalfopristin)

DO NOT REFRIDERATE - CORRECT ANSWERS -**Dear Sweet Pharmacist, Freezing
Makes Me Edgy**
Dexamedetomidine (Precedex)
Sulfa/Trimeth (Bactrim)
Phenytoin
Furosemide
Metronidazole
Moxifloxacin
Enoxaparin

Common LIVE vaccines - CORRECT ANSWERS -**COZY IV RM***
Cholera (PO) (Vaxchora)
Oral Typhoid (PO) (Vivotif)
Zoster (Zostavax)
Yellow Fever
Intranasal Influenza (Flu-Mist)

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