NR 546 NP DEMENTIA | MEDICATION| TABLE | 100% CORRECT
Drug Name and Class FDA Indication (include stages ) Neurotransmitters Affected/Mechanism of Action Target Symptoms Short-acting, intermediate-acting, or long-acting.
Duration of Action and Half-life (T1/2),
CYP 450 enzyme Notable...
NR 546 NP DEMENTIA | MEDICATION| TABLE | 100% CORRECT
Drug Name and Class FDA Indication (include stages ) Short-acting, Notable Side Effects/Precautions /Patient Education
Neurotransmitters intermediate-acting, or Instructions
Affected/Mechanism of Action long-acting.
Target Symptoms Duration of Action and
Half-life (T1/2),
CYP 450 enzyme
Donepezil (Aricept) FDA Indication (include stages): Long-acting Notable Side Effects
243 • Alzheimer's disease (mild, • Metabolized by CYP450 Nausea, diarrhea, vomiting, appetite loss, increased
moderate, and severe) 2D6 and CYP450 3A4 gastric acid secretion, weight loss
• Memory disorders in other • Elimination half-life Insomnia, dizziness
conditions approximately 70 hours Muscle cramps, fatigue, depression, abnormal
• Mild Cognitive Impairment dreams
, Neurotransmitters Precautions
Affected: Should be used cautiously in those with cardiac
Acetylcholine impairment due to reported syncopal episodes
Mechanism of Action: Not recommended for use in pregnant women or
Inhibits centrally active those planning to become pregnant
acetylcholinesterase Not recommended for nursing women
making more acetylcholine May exacerbate asthma or other pulmonary disease
available which Increased gastric secretion may lead to increased risk
compensates in part for of ulcers
degenerating cholinergic Increased risk for heart block of bradycardia
neurons in the neocortex that
regulate memory Patient Education
Medication does not alter underlying disease but can stabilize
Target Symptoms: or relieve symptoms.
Memory loss in Alzheimer's disease Medication should be taken before bed.
Behavioral symptoms in Do not crush or break tablets
Alzheimer disease Report any adverse effects or changes in health status
Memory loss in other immediately to prescriber.
Dementias Use OTC cold or sleep remedies with caution due to
anticholinergic effects.
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