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NUR 909 Quiz 1 With Complete Solution
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NUR 909 Quiz 1 With Complete Solution...
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NUR 909 Quiz 1 With Complete SolutionAbsorption - Answer the movement of a drug from the site of administration into
circulation
Pharmacokinetics - Answer The process by which drugs are absorbed, distributed
within the body, metabolized, and excreted
Intravenous advantages - Answer - Ideal for emergency use
-Large volumes can be administered
Intravenous disadvantages - Answer -Frequent admin
-Infection risk
-Vasculitis
Subcutaneous advantages - Answer -Appropriate for self admin
-Good option for drugs that are rapidly degraded in stomach
Subcutaneous disadvantages Answer Volume of injection is limited to 2mL, rotation of
sites is required.
Oral advantages Answer Convenient, inexpensive, self-administration
Oral disadvantages Answer Poorly absorbed medications/drugs, dysphagia, vomiting,
feeding tubes not recommended
Intramuscular advantages Answer Volumes of 2-5 mL can be administered. It allows for
, sustained drug action.
Intramuscular disadvantages Answer Painful, muscle damage, hemorrhage risk with
anticoagulants
Bioavailability Answer The proportion of the given dose that is able to reach systemic
circulation.
Why does vancomycin need to be given IV in order to treat systemic infection? - Answer
Vancomycin has poor oral bioavailability and is degraded within the stomach and
intestines before it reaches the bloodstream to have any therapeutic effect on a
systemic infection; therefore, it is given IV for better efficacy.
First- pass metabolism - Answer the metabolism of part of a medication before it
reaches systemic circulation. This effect is associated with oral administration
What is a prodrug - Answer A prodrug is an inactive parent compound that requires
metabolic conversion in order to exert its desired pharmacologic effect
Advantages of prodrugs - Answer - Help improve medication effectiveness
- Designed to avoid certain side effects or toxicities
- Crucial in the design of new drugs
Disadvantages of prodrugs - Answer - chemical instability
- low aqueous solubility
- extensive presystemic metabolism
- insufficient absorption
- toxicity
Bioequivalence - Answer Comparative therapeutic activity of chemically identical drugs.
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