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RBC EXAM QUESTIONS AND ANSWERS
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RBC EXAM QUESTIONS AND ANSWERS
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RBC EXAM QUESTIONS AND ANSWERSRBC Membrane Function - Answers-seperate intra- and extra-cellular environments
permeability/nutrient and ion transport
deformability (to pass through capillaries)
what deficiency causes an increased plasma cholesterol/accumulation of cholesterol on
RBC membrane?
what RBC deformities occur as a result of this? - Answers-lectithin-cholesterol acyl
transferase (LCAT) deficiency
target cells & spiculated cells
excess membrane cholesterol is seen in...
As RBC differentiation progresses, the intermediate erythroid progenitor cells formed
are decreasingly/increasingly responsive to BPA and decreasingly/increasingly
responsive to erythropoietin - Answers-decreasingly
increasingly
Hgb levels of ages & genders - Answers-highest in babies up until 6 months
males higher than females
Spectrin functions - Answers-peripheral (confined to cytoplasmic side)
RBC integrity
binds w/ other proteins to form cell "skeleton"
controls biconcave shape & deformity of cell
RBC lifespan - Answers-120 days
dependent on RBC membrane structure & chemical composition
deformability of RBC uses...
What happens as a result of using this? - Answers-ATP
loss of ATP -> decreased phosphorylation of spectrin -> loss of membrane deformability
loss of ATP -> increased membrane calcium -> increased membrane rigidity -> loss of
pliability
spleens purpose in less deformable RBCs or portions of membrane? - Answers-to
isolate less deformable RBCs
, what is freely permeable to RBC membrane? - Answers-water and anions (chloride and
bicarbonate)
what is impermeable to RBC membrane? - Answers-cations (Na & K) requires ATP to
pump in & out
What are two permeability properties of RBC membrane? - Answers-prevent colloid
osmotic hemolysis
control volume of RBC
what percent of Hgb is made in nucleated RBCs? reticuolocytes? - Answers-65%
35%
Hgb structure - Answers-globin - tetramer of 2 pairs of polypeptide chains
4 heme molecules
What is inside of a heme unit? - Answers-protoporphyrin ring + one iron atom, combines
with oxygen
3 pathways involved in hemoglobin synthesis - Answers-iron metabolism
porphyrin synthesis
globin chain (protein) synthesis
How is iron delivered to cells? - Answers-through transferrin, goes to mitochondria to be
inserted into protoporphyrin ring to form heme
Porphyrin synthesis - Answers-
major rate limiting step in heme synthesis, also inducible by the addition of steroids,
erythropoietin, barbiturates - Answers-succinyl coenzyme A + glycine -> delta-
aminolevulinic acid
Which steps of porphyrin production occurs in the cytoplasm - Answers-formation of
porphobilinogen, 4 porphobilinogens join to form uroporphyrinogen, uroporphyrinogen
decarboxylase forms coproporphyrinogen
which isomer leads to heme formation? - Answers-UPG type III
where does this rxn take place?
coproporphyrinogen III -> protoporphyrinogen IX - Answers-mitochondira
porphyrinogen characteristics - Answers-physiologic intermediate in heme synthesis
reduced, unstable, colorless
irreversibly oxidized to porphyrins
porphyrin characteristics - Answers-molecule w/ alternating single and double bonds
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