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General Internal Medicine Part 1 (ABIM) questions with correct answers
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General Internal Medicine Part 1 (ABIM) questions with correct answers
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General Internal Medicine Part 1 (ABIM)Drug Interactions: What Increases INR w/Warfarin? - correct answer ✔✔acetaminophen; pysch (SSRI),
cardiac (amiodarone), antibiotics (fluroquinolones, macrolides, metronidazole, azole antifungals,
TMP/SMX), cholesterol (statins, gemfibrozil)
Drug Interactions: Agranulocytosis - correct answer ✔✔clozapine (held of PMN < 1,000), methimazole/
propylthiouracil, carbamazepine
Drug Interactions: Nephrotoxicity - correct answer ✔✔cisplatin, topiramate, tenofovir, calcineurin
(cyclosporine, tacrolimus), BK polyoma virus (tubulointerstitial nephritis), celecoxib
Drug Interactions: Peripheral Neuropathy - correct answer ✔✔leflunomide, cisplatin
Drug Interactions: Hyperkalemia - correct answer ✔✔NSAIDs, antibiotics (TMP/SMX), cardiac
(ACEi/ARBs/spirnolactone), anti-coag (heparin)
Drug Interactions: Hypomagnesemia - correct answer ✔✔GI (diarrhea, malabsorption), renal (diuretics)
drugs (PPI), alcohol, electrolytes (↓K, ↓Ca)
Drug Interactions: Breast Cancer Medications that cause DVT - correct answer ✔✔tamoxifen (pre-post
menopausal; endometrial hyperplasia-carcinoma), raloxifene (postmenopausal osteoporosis)
Drug Interactions: Hyperammonemia - correct answer ✔✔valproic acid, cirrhosis, GI bleed, ill; (tx-
lactulose, L-carnitine)
Drug Interactions: Optic Neuropathy - correct answer ✔✔linezolid, sildenafil, ethambutol, bevacizumab,
infiliximab, amiodarone
, Drug Interactions: How to Assess Increased Thyroxine Requirements? - correct answer ✔✔compliance,
dosing timing (1hr before breakfast, 1hr before meds), malabsorption (celiac), drugs (iron,
sucralfate/PPI/antacids, Ca; psych- phenytoin, carbamazepine, rifampin)
Drug Interactions: What Hormones Impact Thyroxine Requirements? - correct answer
✔✔estrogen/raloxifene: ↑thyroid requirement
testosterone: ↓thyroid requirement
Drug Interactions: Musculoskeletal Pain Differential - correct answer ✔✔bisphosphonates, statins,
hypothyroid, polymyalgia rheumatica
Drug Interactions: Digoxin Toxicity - correct answer ✔✔GI (abdominal pain, nausea), ophthalmologic
(blindness, color changes), cardiac (narrow complex); (tx-IV hydration + digoxin antibody)
Drug Interactions: QT Interval Prolongation - correct answer ✔✔nausea (zofran, phenergan), antibiotics
(macrolides, quinolones), psych (TCA, SSRI), cardiac (amiodarone), pain (methadone)
Drug Interactions: Medications Interacting with Simva/Lova/Atorvastatin - correct answer ✔✔cardiac
(amiodarone, amlodipine), antibiotic (clarithromycin, azoles), grapefruit juice
Drug Interactions: Hyponatremia - correct answer ✔✔psych (carabamazepine, SSRIs), thiazide diuretics
Drug Interactions: Uric Acid - correct answer ✔✔thiazide diuretics, niacin, cyclosporine
Drug Interactions: Crystal Induced Acute Kidney Injury - correct answer ✔✔acyclovir, sulfonamides,
methotrexate, ethylene glycol, protease inhibitors, uric acid (tumor lysis syndrome); dx-urine sediment
for crystals
Drug Interactions: Antiepileptic Drugs - correct answer ✔✔↓OCP (phenytoin, phenobarital,
carbamazepine, topiramte)
Drug Interactions: Anti-epileptic Drugs Adverse Reactions - correct answer ✔✔-phenytoin-gingival
hypertrophy, horizontal nystagmus, ataxia, slurred speech
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