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Questions and answers for HTHSCI 3I03: Innate Immunity IV
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Questions and answers for HTHSCI 3I03: Innate Immunity IV
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1-64 of 64Leukocytes
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What type of cells migrate to site of infection?
,- Small proteins (15-25kDa) released by cells
- Can act in intracrine, autocrine, justacrine, paracine, endocrine, and exocrine
manner
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Cytokines
Vascular Cell Adhesion Molecule
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What does VCAM stand for?
- Complement, cytokines, chemokines, phagocytes, natural killer cells
- Activation of macrophages
- Dendritic cells migrate to lymph nodes to initiate adaptive immunity
- Blood clotting to help limit spread of infection
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What protects against infection when tissues have been infected?
Local inflammation
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, What is the cornerstone of a successful vaccine?
- Tissue distribution: activated endothelium
- Sialyl-Lewis
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E-selectin
- Bind to cell-adhesion molecules and extracellular matrix
- Strong adhesion
- aL:B2, aM:B2, ax:B2, a5:B1
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Integrins
1. Macrophages activated in the liver and spleen secrete TNF-a into the bloodstream
2. Systemic edema causing decreased blood volume, hypoproteinemia, and
neutropenia, followed by neutrophilia. Decreased blood volume causes collapse of
vessels.
3. Disseminateed intravascular coagulation leading to wasting and multiple organ
failure.
4. Death
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