1. Chemokine CCL21 attracts immature B cells to HEV
2. Chemokines CCL21 and CCL19 attract B cells into lymph node
3. Chemokine CXCL13 attracts B cells into the primary follicle
4. Interactions with follicular dendritic cells and cytokines drives the maturation of
immature B cells
5. Mature B cells recirculate between lymph, blood, and secondary lymphoid tissues
Give this one a go later!
, Steps in B cell positive selection (5 - specific)
Fighting the current infection
Give this one a go later!
Antibody-secreting plasma cell
IgM of immature B cell binds to soluble univalent self antigen. The B cell is signalled
to make IgD and to become unresponsive to antigen, and then enters the peripheral
circulation but does not survive for long.
Give this one a go later!
How does an anergic B cell develop?
1. Stem cell: u germline
2. Early pro-B cell: u germline, κ/λ germline
3. Late pro-B cell: uDJ, κ/λ germline
4. Large pre-B cell: uVDJ, κ/λ germline
5. Small pre-B cell: uVDJ, κ/λ germline
6. Immature B cell: uVDJ, κ/λ VDJ
Give this one a go later!
Cell types in B cell development: bone marrow
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller codersimon. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $8.00. You're not tied to anything after your purchase.