Exam (elaborations)
HE303 Week 5 questions and answers
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HE303 Week 5 questions and answers
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1-121 of 121TCR signal 2: CD28 binds to CD80/86, leads to the activation of __________________ which
activates ________________________, this allows for production of second messengers and
leads to activation of transcription factors AP-1 NF-kB and NFAT
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, PI3 kinase
PLC-gamma
anergy= still alive but ________________ to stimulants
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not responsive
recombine a single gene segment of each V(D)J and connect it to a C domain to make
a _______________________________
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functional receptor gene
there are only 2 adaptive immune receptors ______________ and ______________ they are both
members of the immunoglobulin (Ig) superfamily. they recognise pathogens and
initiate adaptive immune responses
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BCRs and TCRs
Th1 CD4+ T cells produce _________________ which suppresses Th2 development
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IFN-gamma
CD80/86 expression is up-regulated by ___________________________________
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APCs sensing PAMPs using their PRRs
TCR alpha and delta genes are found on ______________________ and contain multiple V,D,J
exons
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chromosome 14
MHC = ______________________ (genes for MHC all together in a single location on
chromosome 6)
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major histocompatibility complex
the immunoproteasome preferentially degrades proteins to produce _____________________
(8-10 aa in length) Cap changes to increase rate of peptide release
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MHC class I compatible peptides
many combinations of _________________
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V(D) and J
Class I MHC are expressed on _______________ and present intracellular peptides to TCR
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every cell in the body
if a T cell gets signal 1 without signal 2 the T cell becomes _______________
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anergic
CTLA-4 inactivates the T cell, blocks antigen presentation and switches off the
___________________ (PD_1 also inactivates T cells on lymphocytes) CTLA-4 and PD-1 blockers
are used in cancer treatments
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