Corticosteroids/glucocor What hormones are produced by the adrenal gland
ticoids/steroids and maintain homeostasis?
Cortisol What is an endogenous glucocorticoid?
1. Glucocorticoids What are the 3 categories of steroid hormones?
2. Mineralcorticoids
3. Adrenal Sex Hormones
1. Inhibits the immune and What is the MOA of corticosteroids?
inflammatory system
2. Inhibits arachidonic
acid metabolism
3. Inhibits production of
ILK-1, TNF, and other
cytokines
4. Impairs lymphocytes
and inhibits tissue repair
hydrocortisone, Examples of glucocorticoid medications
prednisone,
methyprednisolone,
dexamethasone
Life-threatening What is long-term glucocorticoid use indicated for?
conditions or severe
disabling symptoms
, 10/4/24, 6:47 PM NURS 615 PHARM EXAM 3 – MARYVILLE ACTUAL EXAM 2024 EXAM COMPREHENSIVE QUESTIONS WITH DETAILED …
What is short-term glucocorticoid use indicated
Self-limiting conditions
for?
1. Osteoporosis What are the adverse effects of glucocorticoids
2. Worsens diabetic after 6 months of use?
control and increases
blood glucose (diabetics
need more insulin)
3. Promotes gastric
secretion and causes
abdominal pain, N/V
(Report black tarry
stools)
When does bone density begin to decline because
Within the first 3 months of a decrease in calcium from glucocorticosteroid
use?
1. Retains sodium and General adverse effects of glucocorticosteroids
water
2. Increases appetite
3. Promotes fat deposit in
cervical area and face
4. Increases uric acid
5. Delerium, insomnia,
mood alterations, anxiety
6. Adrenal suppression
7. Poor wound healing,
thin skin, acne, ocular
damage
1. To avoid recurrent Why must glucocorticosteroids be tapered?
activity of underlying
disease
2. To avoid possible
cortisol deficiency
resulting from the HPA
axis and HPA suppression
during steroid therapy
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