100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Lecture Notes - Tumor Immunology - week 1 $4.31
Add to cart
Quickly navigate to
Preview
  2.  
  3. Vrije Universiteit Amsterdam (VU)
  4.  
  5. Tumor Immunology

Class notes

Lecture Notes - Tumor Immunology - week 1
 1 purchase
  • Course
  • Tumor Immunology
  • Institution
  • Vrije Universiteit Amsterdam (VU)
  • Book
  • Janeway\'s Immunobiology

Lectures included: basic tumor immunology, cross-priming & cross-presentation, cross-talk between DC & macrophage in cancer, glycan alterations in immune escape mechanism, tumor & inflammation, MDSC/myeloid-derived suppressive cells, recombinant viral vector as cancer vaccine, tumor-immune cells in...

[Show more]

Preview 4 out of 60  pages

Document information

  • January 9, 2020
  • 60
  • 2018/2019
  • Class notes
  • Unknown
  • All classes

Subjects

  • tumor immunology
  • mandatory courses master oncology vu amsterdam

Connected book

book image

Book Title:

Author(s):

  • Edition:
  • ISBN:
  • Edition:

More summaries for

  • Purdue Bio 537: Immunobiology Exam 2 Study Guide
  • Purdue Bio 537: Immunobiology Exam 1 Study Guide
All for this textbook (2)

Written for

  • Vrije Universiteit Amsterdam (VU)
  • Oncology
  • Tumor Immunology
All documents for this subject (6)

Seller

avatar-seller
oddsters

Content preview

Module 2: Tumor Immunology (Week 1)

LECTURE 1: BASIC TUMOR IMMUNOLOGY Monday 1/10/2018




1. Lymphoid-Myeloid differentiation patterns

Cellular elements of blood arise from pluripotent HSC in the bone marrow. HSC produces 2 types of progenitor
cells: lymphoid progenitor & myeloid progenitor. B cells (differentiate in bone marrow) & T cells (differentiate in
thymus) have antigen receptors; other cells do not. Unlike B/T cells, ILC (innate lymphoid cells) & NK cells lack
antigen specificity.

Differentiated B cells  plasma cell, T cell  effector T cell (T helpers, T cytotoxic, T regulatory).

Immature dendritic cells (DC): enter tissue and act as phagocytic cells, matures after contact with antigen; DC can
be derived from myeloid/lymphoid progenitors. Monocytes: entering tissues  differentiate into macrophages

Mature DC DO NOT PHAGOCYTISE

2. Defense systems against pathogens

Epithelium: most important barrier against pathogens, if disrupted  require help from immune system

Chemical & enzymatic elements (complement C3, defensins, etc) + innate immune cells (macrophage,
granulocyte, NK)  provide rapid cell-mediated response when epithelium is breached

, Module 2: Tumor Immunology (Week 1)

Adaptive immune response  slower process, able to induce memory to provide faster & more efficient
response on 2nd exposure to the same antigen



3. Adaptive response (antibody-mediated)




Lag phase: body produces antibodies  pathogens are being neutralized by cellular response.

Primary response: immunoglobulin level increases in serum (decreases when infection is overcome).

Secondary response: quicker & higher effectivity on 2nd encounter (memory cells involvement  don’t need
much activation).

4. Antigen-presenting cells (APC) – key players in immune system

2 professional APC: dendritic cells & macrophages  taking up antigens to break them down (into oligopeptides)
& present them to MHC class I/II. DC: watchdogs of the body, always patrolling for abnormal cells, Macrophages:
scavengers

DC maturation: precursors in bone marrow (marker: CD34+)  exposed to cytokines (GM-CSF, IL-4) 
immature DC (in resting/non-infected tissue, can only take up antigen, marker: CD1a+)  exposure to antigen OR
presence of other cytokines (TNF alpha, CD40, LPS, GM-CSF, IL-4)  mature DC (able to take up antigen & present
antigen to MHC, marker: CD83+)

, Module 2: Tumor Immunology (Week 1)

Tumor antigen processing by APC:

Tumor starts growing, some dies d/t necrosis  release tumor
antigens  tumor antigens recognized by DC  taken up by DC
& into lymph nodes  exposure of DC & tumor antigen to naïve T
cells  T cell maturation (bound to DC)  activation &
proliferation of T cells  T cells migrate to tumor site 
eradication by apoptosis




5. Mellman cancer immunity cycle

Destruction of tumor cells by chemotherapy,
radiation, or targeted therapy  releasing
TAA/TSA  TAA/TSA taken up by APC (uptake
can be enhanced by vaccine, IFN alfa, GM-CSF,
CD40 agonist, or TLR agonist)  antigen
presentation  priming & activation of naïve T
cells (enhanced by anti-CTLA4, IL-2, IL-12, etc) 
activated T cell migrates into tumor
microenvironment  infiltrate TME  recognize
cancer cells (enhanced by CAR)  killing of tumor
cells (enhanced by anti-PD1/PD-L1, IDO inhibitor)

, Module 2: Tumor Immunology (Week 1)

6. DC activity

DC receptors:

a. Fc receptor: binds to antigen-antibody
complex  internalization
b. Toll-like receptors (TLR): binds viral &
bacterial antigens, can also bind to certain
ligands
 Type I/II TLR: bacteria
 Type III TLR: viral dsDNA (specific)
 Type IV TLR: endotoxin/LPS
 Type IX TLR: CpG hypomethylation
(virus/bacteria)
c. CD36 receptor: binds apoptotic bodies
d. CD91 receptor: binds heat shock proteins




Immature DC is activated via its TLR when presented to microbes  receptor ligands can also bind to TLR to
mimic actual bacterial infection (i.e. vaccination strategy)

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller oddsters. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $4.31. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

69052 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 15 years now

Start selling
$4.31  1x  sold
  • (0)
Add to cart
Added