Describe effect on low and high albumin levels on active drug levels especially for drugs that are highly protein bound Albumin is the plasma protein with the greatest capacity for binding drugs. Binding plasma proteins affect drug distribution into tissues, because only drug that is not bound is...
Describe effect on low and high albumin levels on active drug levels
especially for drugs that are highly protein bound Albumin is the
plasma protein with the greatest capacity for binding drugs. Binding
plasma proteins affect drug distribution into tissues, because only drug
that is not bound is available to penetrate tissues, bind to receptors,
and exert activity. As free drug leaves the blood stream, more bound
drug is released from binding sites.
Identify 2nd degree heart block permanent pacemaker, continuous
tele monitoring, possible transcutaneous pacing, determine cause; IV
atropine if poor perfusion s/s every 3-5 minutes with max of 3mg if
poor perfusion. No response to atropine, use dopamine, epinephrine,
isoproterenol
Describe factors that affect excretion affected by abnormal kidney
or liver function, age, drug interactions
Identify 3rd degree heart block/complete heart block Permanent
pacemaker, telemetry monitoring and transcutaneous pacing if needed,
identify cause, IV atropine if s/s poor perfusion. If no response to
atropine, use dopamine, epinephrine and isoproterenol
, Highly protein bound drugs can lead to toxicity in patients with low
albumin levels, example malnutrition or chronic illness. This is because
there are fewer than the normal sites for the drug to bind
Describe the ways the hepatic first pass effect- which is metabolism
during first pass through the liver Alternative routes include:
suppository
intravenous
intramuscular
inhalational aerosol
transdermal
sublingual
These allow drugs to bypass the first-pass effect and be absorbed
directly into systemic circulation
Be able to calculate creatinine clearance using Cockgraft Gault
equation: Male = 140-age times weight in kilograms divided by
serum creatinine times 72.
Women = CRCL (male) times 0.85
Describe what determines the frequency of drug administration
half life
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