Summary
Summary BMS 300 Exam 2 Study Guide
- Course
- Bms 300
- Institution
- Colorado State University
This is a comprehensive and detailed study guide on Exam 2 for Bms 300. *Essential Study Material!!
[Show more]
Content preview
Nervous System--Exam 22/20 Neurons
● Structure
○ Dendrite
○ Cell body
○ Axon
○ Axon terminal
● Function
○ Input: contains ligand-gated channels (synaptic potentials)
○ Conductile: contains voltage-gated channels (action potentials)
○ Output: voltage-gated Ca2+ channels (exocytosis)
○ Cell biology of neurons
■ Logistics of an asymmetric cell
● Anterograde transport
● Retrograde transport
■ Transport Rates
● 1. Fast: 200-400 mm/day vesicular protein
● 2. Slow: 0.5-2 mm/day cytoplasmic protein
○ Slow transport as intermittent fast transport
○ Experiments to separate slow and fast transport
2/24 Physiology of Excitable Cells
● Generating the Membrane Potential
○ The K+ Battery
■ Plasma membrane
■ Permeability to K+ ions 1st selective leak channels
■ A- inside cell: impermeant
○ The Nernst Potential- The K+ Equilibrium Potential
𝑅𝑇 𝐾0
■ 𝐸𝑘 = 𝑍𝐹
𝑙𝑛 𝐾𝑖
■ R= gas constant
■ F= Faraday
■ z= ion change
■ T= temp. in K
● Role of the Na+ Channel
○ Na+ selective channel
○ Channel can open and close
● Role of Ion Permeability
○ The membrane potential seeks the equilibrium potential for the ion whose
permeability is dominant
● Generating the Action Potential
○ 1st leak
○ V-gated Na+ channels open then inactivate
, ○ Role of charged in v-gated Na+ channel opening
○ Concept of threshold potential propagation
● Nodes of Ranvier: regions of naked axonal membrane where voltage-gated channels
duster
● Internodal regions
○ Regions of axon ensheathed by concentric layers of myelin
● Myelin formation in CNS by oligodendrocytes
● Schwann cells in PNS
○ Form myelin wraps around axons in PNS
● Multiple Sclerosis as a disease of oligodendrocytes
● Role of Schwann cells and oligodendrocytes in neuronal degeneration
●
PNS Glia ← Glia → CNS Glia
Glial Cells, Schwann cells, Astrocytes: regulate the
neurolemmocytes extracellular environment
in CNS
Responsible for forming Oligodendrocytes:
myelin wraps around producing insulating wraps
axons/conductile regions in around conductile/axonal
PNS regions in cells
Microglia (macrophages):
cells of immunity
●
2/26 Action Potential Generation and Propagation
● Leak channels
○ Set the resting membrane potential
● Voltage-gated Na+ channels
○ Charge sensitive
○ Depolarize membrane potential towards ENa
○ Inactivate shortly after opening have threshold for opening
● Voltage-gated K+ channels open
○ Charge sensitive
○ Slower opening than Na+ channels delayed Rectifier
● Action potential propagation
○ In membranes where v-gated channels clustered at one site
○ In membranes where v-gated channels are distributed along unmyelinated
○ In membranes where v-gated channels myelin clustered at nodes of ranvier
2/27 Action potential propagation in myelinated axons
● Propagation in unmyelinated axons
○ Uniform distribution of v-gated channels
○ Role of membrane capacitance
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller anyiamgeorge19. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
52928 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now