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Percy Pathology of Lab Animals – Mouse fully solved & updated.
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Percy Pathology of Lab Animals – Mouse fully solved & updated.
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Percy Pathology of Lab Animals– Mouse fully solved & updated
C57BL/6 strains
"background strain"
neoplasia: lymphoma, hemangiosarcoma, pituitary adenoma
predisposed to barbering with alopecia and staph dermatitis
Balb/c (white) strain
pugilistic males
-dystrophic mineralization of the heart with myogeneration and
auricular thrombosis
-prone to corneal opacity with conjunctivitis, periocular abscesses
**Resistant to spontaneous amyloidosis
neoplasia: pulmonary adenomas, lymphoma, Harderian gland
tumors, adrenal adenomas
C3h/HE (brown)
rdl mutation --> blind
susceptible to murine mammary tumor virus - High incidence of
mammary neoplasia
,129 (brown) mice
testicular teratomas
Most frequent source of embryonic stem cells
FVB/N mice (white)
rd1 mutation --> blind; and prone to seizures
neoplasia: lung and liver tumors, lymphoma, pheochromocytoma,
prolactin secreting adenomas in the pituitary gland --> persistant
mammary hyerplasia
NOD (white)
bred for cataracts
develop Type I diabetes
common development of autoimmune disorders - defects in
macrophages, dendritic cells, NK cells, regulatory T cells
, Murine Adenovirus 1
-fatal multisystemic infection in neonates and immunodeficient mine
(subclincial in immunocompetent)
-hemorrhagic encephalomyelitis in susceptible strains, Especially
in White matter
Foci of necrosis in liver, spleen, other organs with intranuclear
inclusions
Histo: foci of necrosis and hemorrhage in numerous organs
(predominantly epithelium);
ddx: cytomegalovirus, polyomavirus
Murine Adenovirus 2
-enterotropic
histo: minimal;
IN inclusions within enterocytes in the distal small intestine and
cecum (PATHOGNOMONIC but variable present);
nucleus will be apical, not basilar
Mouse cytomegalovirus (betaherpesvirus)
Spread by direct contact
histo: enlarged cells with IN AND IC inclusions, most numerous in
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