Test Bank Solution Manual for Blood Banking Reagents Already Passed
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Course
Blood Bank
Institution
Blood Bank
Test Bank Solution Manual for Blood Banking Reagents Already Passed
Reagent RBCs - Answers commercially prepared
known source of Ag
Patient or Donor RBCs - Answers usually an unknown source of Ag
RBCs are tessted w/ commercial antisera to determine Ag ID
Reagent antisera - Answers commercial...
Ab Screen - Answers detects Abs with specificity to RBC Ags
Source of Ag: screening cells
Source of Ab: pts serum/plasma
Ab ID - Answers ID specificity of RBC Abs
Source of Ag: Panel cells
Source of Ab: pt serum/plasma
Crossmatch - Answers determines serologic compatibility btwn donor and pt before transfusion
Source of Ag: Donor RBCs
Source of Ab: pt serum or plasma
4 Basic Categories of Reagents - Answers RBCs with known Ags
, Antisera w/ known Abs
Antiglobulin reagents: anti-IgG and or complement
Potentiators to enhance Abs
Reagent Regulation - Answers FDA's criteria:
Reagents must meet minimum standards before being licensed
Specificity: recognition of the antigenic determinant and its corresponding Ab
Potency: strength of the reaxn
Polyclonal Abs - Answers Made from several different clones of B cells that secrete antibodies of
different specificities
Recognize multiple epitopes
Example: antihuman globulin (AHG)
Monoclonal antibodies - Answers Made from single clones of B cells that secrete antibodies of the same
specificity
Use hybridoma- a hybrid cell formed by the fusion of a myeloma cell and an antibody-producing cell; it is
used in the production of monoclonal antibodies.
technology
Recognize a single epitope
Examples: anti-A, anti-c, and anti-IgG antibodies
ABO Typing - Answers Anti-A and anti-B reagents are used to determine the ABO blood type
Both antisera are directed toward specific antigens on the patient's RBCs
Anti-A: directed toward A antigen
Anti-B: directed toward B antigen
ABO Typing (cont'd) - Answers Reagents are formulated to give a strong reaction (3+ to 4+)
Testing is performed in the immediate-spin (IS) phase
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