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UNE BIOCHEMISTRY FINAL EXAM QUESTIONS AND ANSWERS
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UNE BIOCHEMISTRY FINAL EXAMQUESTIONS AND ANSWERS
What are the direct products of beta-oxidation? - ANSWER NADH.
FADH2
Acetyl CoA
What is Acetyl CoA used for? ANSWER ketogenesis.
allosterically activates Pyruvate Carboxylase.
The father of an 11-year-old girl brings her to the emergency department. He
claims she has recently been quite thirsty and requires frequent trips to the
restroom. She complained of lightheadedness during her soccer game today, and
the symptoms persisted even after she drank a power drink. A fast dipstick test
detected glucose in her urine, and subsequent testing confirmed a diagnosis of
Type 1 Diabetes. An evaluation of the liver would reveal an increase in which
of the following processes? - ANSWER Ketogenesis
What is the role of adipose tissue in metabolism? - ANSWER Storage of
triacyglycerols
appetite control, coagulation, immunity, and reproduction.
A 5-year-old female is brought to the ED by her mother. She is a type 1 diabetic
who has not taken her insulin while attending a day camp. The child is
unresponsive. Which of the following enzymes is phosphorylated and functional
under given conditions? - ANSWER: hormone-sensitive lipase
,An individual goes to bed at 8 p.m. and doesn't get up until 9 a.m. the next day.
During this time, which of the following is the predominant oxidizable substrate
in skeletal muscle? - Answer: free fatty acids.
A person is on hunger strike and hasn't eaten in 13 days. Which of the following
accurately reflects their metabolic state? - ANSWER: The brain will
preferentially oxidize ketones.
In the fasting state, fatty acyl-CoAs cross the mitochondrial membrane. Which
of the following substances can directly impede fatty acid transport via carnitine
palmitoyl transferase I (CPTI)? - Answer: Malonyl CoA.
Which of the following enzymes will be activated by increased glucagon during
fasting (insulin-to-glucagon ratio <1)? - Answer: Hormone Sensitive Lipase.
A healthy 2-year-old girl comes to the clinic with symptoms of a viral disease.
Her parents claim that she has experienced bouts of vomiting and diarrhea in the
past 24 hours. This morning, they could barely wake her from her cot since she
was so weak. Laboratory tests reveal hypoglycemia (low blood glucose) and
increased liver enzymes. There are no ketones in her urine. The child is
hospitalized, and glucose is supplied intravenously. Additional laboratory tests
revealed higher levels of medium-chain fatty acyl carnitines in the blood and 6-
8 carbon dicarboxylic acids in urine. Which of the following anomalies is the
most probable diagnosis for this child? - ANSWER Defect in medium-chain
acyl-dehydrogenase
A 22-year-old lady participating in a political protest goes on hunger strike on a
conspicuous corner of a local park. For the first two weeks, she ignores all meal
options except water. Which of the following fuel paths is less likely to be used
under given conditions? - ANSWER: Gluconeogenesis
, ATP can be produced by numerous metabolic pathways in the body. Which one
of the following procedures produces the most ATP? - ANSWER: Fatty acid
beta-oxidation
In the liver, which of the following essential inhibitory actions prevents freshly
produced palmitoyl-CoA from being oxidized right away? - ANSWER
Malonyl-CoA inhibits carnitine-palmitoyl transferase I (CPT-I).
Which of the following enzymes will increase as the insulin-to-glucagon ratio
rises? - Answer: hormone-sensitive lipase diminishes.
Acetyl CoA carboxylase increases
Phosphofructokinase 2 rises.
Glycogen synthase rises
NADPH is required for fatty acid synthesis and can be produced by which two
enzymes? (+) indicates that the enzyme can create NADPH; - indicates that the
enzyme does not produce NAPDH.
Which of the following enzyme complex activities would be affected by a
malfunction in the thioesterase subunit of fatty acid synthase? - ANSWER
Liberation of newly formed palmitate from the enzyme
Malate can be metabolized into pyruvate in the cytosol. Which of the following
chemicals is immediately created during this conversion and is required for fatty
acid synthesis? - ANSWER NADPH
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