Exam (elaborations)
Pathoma Hemostasis and Related Disorders Latest Updated Exam Study Guide 2024
- Course
- Institution
Pathoma Hemostasis and Related Disorders Latest Updated Exam Study Guide 2024
[Show more]
Content preview
Pathoma Hemostasis and RelatedDisorders
Latest Updated Exam Study Guide
2024
primary hemostasis - ansgoal is to make a platelet plug as
a temporary solution to vessel injury
primary hemostasis pic - ans
primary hemostasis: what happens after injury to the
vessel endothelium - ans1. there is transient
vasoconstirction that occurs
- decrease the blood flow to there before any hemostasis
can begin
primary hemostasis: vasoconstriction mediated by - ans1.
neural reflex
2. endothelial cells release endothelin
endothelin - ans
primary hemostasis: after vasoconstriction, then -
ansplatelet adhesion
primary hemostasis: platelet adhesion - ans1. vWF is
released by two sources;
- platelets via the alpha granules
- endothelial cells in the weibel pilade body
2. vWF binds to the exposed subendothelial collagen
- works as a nidus for platelet adhesion
primary hemostasis: after platelet adhesion - ansplatelet
aggregation
,Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
primary hemostasis: platelet activation - ans1. GP1B
receptor binds to vWF
- this causes shape change and activation
primary hemostasis: aggregation - ans1. the platelets
release important molecules such as
1. ADP
- from the desne granules
- induces platelets to express the GPIIbIIIa receptor that is
essental for aggregation
2. thromboxane A2
-- derived from platelet COX
- allows for further aggregation
thromboxane A2 - ans
classic signs and symptoms of disorders of primary
hemostasis - ans1. mucosal and skin bleeding
- epistaxis, hemoptysis, occult blood, hematochezia,
hematuria, menhorragia
2. skin bleeding
- petichiae are small pinpoint
- purpura
- echymosses
,Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
--- easy burising
epistaxis - ans
hemoptysis - ans
occult blood - ansno
hematochezia - ans
hematuria - ans
petichiae - ans
purpura - ans
echymosis - ans
Useful lab studies - ans1. platelet count
2. bleeding time
- bit outdated
3. blood smear
- size,
4. bone marrow biopsy
- are the megakaryocytes normal
idiopathic thrombocytopenic purpura: what it do - ansAI
production of IgG against platelet surface protein
-- e.g. GpIIbIIIa
idiopathic thrombocytopenic purpura: fun fact - ansmost
common cause of thrombocytopenia in the blood in *both
children and adults*
, Pathoma Hemostasis and Related
Disorders
Latest Updated Exam Study Guide
2024
idiopathic thrombocytopenic purpura: IgG - ansthey are
produced by plasma cells in the spleen
then, the Ab bound platelets are alter consumed by the
macrophages in the spleen
idiopathic thrombocytopenic purpura: forms - ansacute
- think children
chronic
- think adults, think ppl with AI disease
idiopathic thrombocytopenic purpura: acute form -
anschildren
1. thrombocytopenia weeks after infection or
immunization
2. self0limiting d/o within weeks of pt
Tx: support, esp. with really bad thrombocytopenia
idiopathic thrombocytopenic purpura: chronic form -
ans1. usually F of child bearing age
2. may be primary or secondary
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller STUVIATUTOR2021. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $20.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75632 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now