PC 707 Final Safety Exam Questions And Complete Answers
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Course
PC 707
Institution
PC 707
PC 707 Final Safety Exam Questions And
Complete Answers
What Black Box Warning does Carbamazepine & Lamictal carry? Potential lifethreatening dermatologic reaction, including Steven's Johnson and Toxic Epidermal Necrolysis
What Black Box Warning does Promethazine (Phenergan)
antiemetic carry...
Proton Pump Inhibitors Increases the risks for ‣ Upon starting: Community acquired
pneumonia
‣ Over time more likely to get infections like TB
‣ Over time possible increased potential for fractures
Bisphosphonates potential risk osteonecrosis of the jaw
As we age, our kidneys become smaller & there is a decrease in renal blood flow. Why is this a
prescribing consideration? Decreased renal clearance of drugs
As we age, our liver become smaller, has decreased blood flow & first pass metabolism
decreases. Why is this a prescribing consideration? Decreased liver size also means
decreased production of CYP 450 enzymes!
So if you need to select a drug for the elderly, try to select drugs that use Phase 2 metabolism
(not affected by age) Phase I is affected & involves the CYPs.
, PC 707 Final Safety Exam Questions And
Complete Answers
AS we age, there is a decrease in total body water by 10-15%! Why is this a concern when
prescribing for the elderly? Decrease in total body water results in decreased distribution
of water soluble medications & causes increased serum levels of drugs.
Why are the elderly at higher risk of Torsades de Points? Elderly tend to be on more
drugs, so more of a chance to have multiple QT prolongation drugs.
Additional risk of TdP with low potassium, *low magnesium* & bradycardia- more common in
the elderly.
Afib more likely
What are the concerns with anticholinergic drugs & the elderly? In the elderly
Anticholinergic drugs can cause:
‣ Memory impairment,
‣ confusion,
‣ falls,
‣ hallucinations,
‣ tachycardia &
‣ acute angle glaucoma
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