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Exam Review: NR668 / NR 668 (Latest 2024 / 2025) Psychiatric-Mental Health Capstone Practicum & Intensive | Questions and Answers | 100% Correct | Grade A - Chamberlain $7.99
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Exam Review: NR668 / NR 668 (Latest 2024 / 2025) Psychiatric-Mental Health Capstone Practicum & Intensive | Questions and Answers | 100% Correct | Grade A - Chamberlain
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Exam Review: NR668 / NR 668 (Latest 2024 / 2025) Psychiatric-Mental Health Capstone Practicum & Intensive | Questions and Answers | 100% Correct | Grade A - Chamberlain Question: Potency Answer: amount of a drug needed to produce a given effect Question: Agonist Answer: Compounds ...

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  • October 13, 2024
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  • 2024/2025
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Exam Review: NR668 / NR 668
(Latest ) Psychiatric-
Mental Health Capstone Practicum
& Intensive | Questions and
Answers | 100% Correct | Grade A -
Chamberlain


Question:
Potency
Answer:
amount of a drug needed to produce a given effect




Question:
Agonist
Answer:
Compounds which give maximal response after receptor occupation and
activation.


Example: Oxycodone

,Question:
Partial Agonists
Answer:
Compounds which activate the receptor but not at the maximal response.


Example Buprenorphine (Suboxone) or Buspirone




Question:
Antagonist
Answer:
Blocks the action of an agonist. Example: Neuroleptics, Naloxone




Question:
Volume of distribution (Vd)
Answer:
amount of drug divided by concentration


A large Volume of distribution may indicate that the drug distributes
extensively into the body.


Vd is a theoretical fluid volume necessary to contain the total amount of a
drug at the same concentration observed in the plasma.

,Sample Question: In renal failure would the Vd be increased or decreased?
Answer: Increased because of fluid retention




Question:
Distribution
Answer:
Plasma protein binding. Cannot leave the circulation easily. Free (unbound)
crosses membranes. Two drugs that are both highly protein bound will
compete with each other. The unbound fraction goes through metabolism
and is responsible for the pharmacologic effects. Drugs that are highly protein
bound and have a narrow therapeutic index can be dangerous because margin
of error between therapeutic and toxic is narrow.


Rapid weight loss may result in drugs being released from fat cells




Question:
Metabolism
Answer:
Mostly in the liver. Biotransformation or change it to inactive form or make it
more water soluble to facilitate excretion. This transformed substance is
called the metabolite. The rate of metabolism is affected by age, liver and
drug tolerance (Body may produce more enzymes and the liver becomes faster
at breaking that particular drug down)

, Question:
½ Life
Answer:
time it takes the peak level to fall by ½




Question:
Steady state of a drug
Answer:
When the rate of drug administration and elimination are equal. This can be
achieved in 4 - 5 half lives




Question:
Phase I reactions
Answer:
Transforms drug, CYP450 Oxidases. Make it available for the body to use




Question:
Phase II reaction
Answer:
Conjugation reactions or attach drug with something. End products tend to
be less active than their substrates

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