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NURS 3550 GENTAMYCIN EXAM WITH ALL ANSWERS.
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NURS 3550 GENTAMYCIN EXAM WITH ALL ANSWERS.
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NURS 3550: GENTAMYCIN EXAM WITHALL ANSWERS
Chapter B87 Bpresents Bthe Baminoglycosides, Bantibiotics Bthat Binhibit Bprotein
Bsynthesis. BThe Bchapter Bbegins Bwith Bthe Bbasic Bpharmacology Bof Bthese Bagents.
B- Bcorrect Banswer-
Aminoglycosides Bare Bnarrow-spectrum Bantibiotics Bused Bprimarily Bagainst B-
Bcorrect Banswer-aerobic Bgram-negative Bbacilli.
Aminoglycosides Bdisrupt B- Bcorrect Banswer-protein Bsynthesis, Bcausing Brapid
Bbacterial Bdeath.
The Baminoglycosides Bcan Bcause Bserious Binjury Bto Bthe B- Bcorrect Banswer-inner
Bear Band Bkidneys. BBecause Bof Bthese Btoxicities, Bindications Bfor Bthese Bdrugs
Bare Blimited.
Aminoglycosides Bare Bhighly B- Bcorrect Banswer-polar Bpolycations. BAs Ba Bresult,
Bthey Bare Bnot Babsorbed Bfrom Bthe Bgastrointestinal Btract Band Btherefore Bmust Bbe
Badministered Bparenterally Bto Btreat Bsystemic Binfections.
, The Baminoglycosides Bare Bbactericidal. BCell Bkill Bis Bconcentration Bdependent.
BTherefore, Bthe Bhigher Bthe Bconcentration, Bthe Bmore Brapidly Ban Binfection Bclears.
B- Bcorrect Banswer-
Bactericidal Bactivity Bpersists Bfor Bseveral Bhours Bafter Bserum Blevels Bhave B-
Bcorrect Banswer-dropped Bbelow Bthe Bminimal Bbactericidal Bconcentration; Bthis
Bphenomenon Bis Bknown Bas Bthe Bpostantibiotic Beffect.
The Bprincipal Bcause Bof Bbacterial Bresistance Bis Bthe Bproduction Bof B- Bcorrect
Banswer-enzymes Bthat Bcan Binactivate Baminoglycosides. BOf Ball Bthe
Baminoglycosides, Bamikacin Bis Bleast Bsusceptible Bto Binactivation Bby Bbacterial
Benzymes.
The Bprincipal Buse Bfor Bparenteral Baminoglycosides Bis Btreatment Bof B- Bcorrect
Banswer-serious Binfections Bcaused Bby Baerobic Bgram-negative Bbacilli.
One Baminoglycoside—gentamicin—is Bnow Bcommonly Bused Bin B- Bcorrect
Banswer-combination Bwith Beither Bvancomycin Bor Ba Bbeta-lactam Bantibiotic Bto
Btreat Bserious Binfections Bwith Bcertain Bgram-positive Bcocci.
The Baminoglycosides Bare Beliminated Bprimarily Bby B- Bcorrect Banswer-the
Bkidneys. BAccordingly, Bto Bprevent Bserious Btoxicity, Bthe Bdosage Bsize Bmust Bbe
Breduced Bor Bthe Bdosing Binterval Bmust Bbe Bincreased Bin Bpatients Bwith Bkidney
Bdisease.
The Baminoglycosides Bcan Bproduce B- Bcorrect Banswer-serious Btoxicity, Bespecially
Bto Bthe Binner Bear Band Bkidneys. BThese Bstructures Bare Bvulnerable Bbecause
Baminoglycosides Bbecome Bconcentrated Bwithin Btheir Bcells.
The Brisk Bof Bototoxicity Bis Brelated Bprimarily Bto B- Bcorrect Banswer-persistently
Belevated Btrough Bdrug Blevels Brather Bthan Bto Bexcessive Bpeak Blevels.
Patients Bshould Bbe Bmonitored Bfor B- Bcorrect Banswer-ototoxicity. BThe Bfirst Bsign
Bof Bimpending Bcochlear Bdamage Bis Bhigh-pitched Btinnitus B(ringing Bin Bthe Bears).
BOtotoxicity Bis Blargely Birreversible. BAccordingly, Bif Bpermanent Binjury Bis Bto Bbe
Bavoided, Baminoglycosides Bshould Bbe Bwithdrawn Bat Bthe Bfirst Bsign Bof Bdamage
B(i.e., Btinnitus, Bpersistent Bheadache, Bor Bboth).
Aminoglycosides Bcan Binjure Bcells Bof Bthe B- Bcorrect Banswer-proximal Brenal
Btubules.
Nephrotoxicity Bcorrelates Bwith B- Bcorrect Banswer-(1) Bthe Btotal Bcumulative Bdose
Bof Baminoglycosides Band B(2) Bhigh Btrough Blevels.
Aminoglycoside-induced Bnephrotoxicity Busually Bmanifests Bas B- Bcorrect Banswer-
acute Btubular Bnecrosis.
Injury Bto Bthe Bkidneys Busually Breverses Bafter B- Bcorrect Banswer-aminoglycoside
Buse Bis Bdiscontinued.
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