NURP 424 Pharm Exam 1 Questions And Answers With Verified Study Solutions
1 view 0 purchase
Course
NURP 424
Institution
NURP 424
NURP 424 Pharm Exam 1 Questions And Answers With Verified Study Solutions
Considerations when prescribing: ANS I: Indication
C: contraindication
P: precautions or interactions
C: cost/compliance
E: efficacy
A: adverse effects
D: dose/duration/directions
Drug approval process: Phase I ANS...
NURP 424 Pharm Exam 1 Questions And Answers
With Verified Study Solutions
Considerations when prescribing: ANS I: Indication
C: contraindication
P: precautions or interactions
C: cost/compliance
E: efficacy
A: adverse effects
D: dose/duration/directions
Drug approval process: Phase I ANS Phase I: safety and safe dosage- how the drug is tolerated at
different doses- does not determine efficacy; studies the pharmacokinetics of the drug
(After the preclinical animal testing phase)
Drug Approval Process: Phase II ANS Phase II: determine dosage and efficacy; determine short-
term risks
Drug Approval Process: Phase III ANS Phase III: controlled and uncontrolled clinical trials of
safety and efficacy in multiple settings; submit a new drug application (NDA) to the FDA
-Is it better than current treatment?
Drug Approval Process: Post Market ANS Phase IV or Post market research: has no fixed
duration, further report adverse events
DEA Controlled Drug Schedules: Schedule 1 ANS - No accepted medical use
-No legal use permitted
- For registered research facilities only
Heroin, LSD, mescaline, peyote, marijuana*(state to state)
,DEA Controlled Drug Schedules: Schedule 2 ANS -No refills permitted (only 30 day supply)
-No phone orders unless you have a written one within 7 days
-E-prescribe is OK
- expires in 72hrs id not filled
Narcotics, stimulants, depressants (phenobarbital, secobarbital)
DEA Controlled Drug Schedules: Schedule 3 ANS -must be rewritten after 6 months or five
refills
-phone and fax OK
Some narcotics (Percocet, hydrocodone) Some stimulants (benzphetamine, chlorpheniramine,
diethylpropion)
Anabolic steroids, testosterone
DEA Controlled Drug Schedules: Schedule 4 ANS -same as schedule 3, penalties for illegal
possessions are different
-low potential for abuse per DEA
pentazocine, phentermine, benzos, meprobamate
DEA Controlled Drug Schedules: Schedule 5 ANS - same as all prescription drugs
-may be dispensed without prescription unless regulated by the state
loperamide, cough meds, pregabalin
Adverse Drug Reactions: Pharmacological ANS - majority of adverse reactions
-predictable
-dose-related
-85-90% of ADRs
(Hypotension from antihypertensives)
Adverse Drug Reactions: Idiosyncratic ANS -unpredictable
, -Not dose-related
(Stevens-Johnson syndrome from lamictal or ibuprofen)
Immune-Mediated ADR: Type 1 ANS -igE mediated, immediate type
-previously sensitize person
-hypersensitivity like atopic dermatitis, hives, angioedema or anaphylaxis
Immune-Mediated ADR: Type 2 ANS - antibody-dependent cytotoxicity
- "autoimmune response"
- improvement with removal of drug
- HIT or hemolytic anemia, neutropenia
Immune-Mediated ADR: Type 3 ANS -immune complex hypersensitivity (Arthus reaction to
tetanus vaccine)
- "serum sickness"
-Aggregates of antigens and IgG create insoluble immune complexes in blood vessels which can take
a week to occur and cause vasculitis
- arthralgia, fever, swollen lymph nodes, and splenomegaly
-involvement of tissue
Immune-Mediated ADR: Type 4 ANS -cell-mediated or delayed hypersensitivity
- Usually occurs more than 12 hours after exposure to the allergen, with a maximal reaction time
between 48 and 72 hrs
-Ex. drug rash, eosinophilia, and systemic syndrome (DRESS), Stevens Johnsons, contact dermatitis
Time-Related ADR ANS -Rapid: during or immediately following admin
-First-dose: occur immediately after the first dose
-Immediate: within one hour of exposure
-Delayed: one hour after exposure
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Nipsey. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.99. You're not tied to anything after your purchase.
