Exam (elaborations)
BMS 602 Mycobacterium Tuberculosis Exam Studty Set
- Course
- Institution
BMS 602 Mycobacterium Tuberculosis Exam Studty Set ...
[Show more]
Content preview
BMS 602 Mycobacterium TuberculosisExam Studty Set
describe Mycobacterium spp. - Answer non motile, non spore forming, aerobic rods,
neither gram negative or positive, generally slow growers in vitro
describe Mycobacterium spp. cell wall - Answer very hydrophobic, peptidoglycan layer
linked to arabinogalactan, mycolic acid layer overlaid with lipis, glycolipids,
peptidoglycolipids and proteins
what was tuberculosis also know as? - Answer great white plague
M. tuberculosis pathogen - Answer acid fast, slow growing, rod
M. tuberculosis encounter - Answer human reservoir (humans are natural reservoir)
M. tuberculosis entry - Answer human to human spread via inhalation of contaminated
respiratory secretions from infected individual
M. tuberculosis spread - Answer spread from site infection via tissue destruction and
lymph system
M. tuberculosis multiplication - Answer colonizes alveolar macrophages, replicating in
specialized vacuole or in cytosol
M. tuberculosis damage - Answer infection may elicit immune response which controls
infection of an immune response that destroys lung tissue
M. tuberculosis diagnosis - Answer culture and microscopy culture sputum, tuberculin
skin test, IFN gamma release test
describe primary infection of M. tuberculosis - Answer begins when contaminated
droplets reach alveoli of the lung,, binds to macrophage and is engulfed by alveolar
macrophages but hasn't been activated by a CD4 T cell therefore cannot digest M.
tuberculosis, M. tuberculosis establishes replicative vacuole, replicates inside
macrophage for 7-21 days, destroys macrophage, recruits macrophages T cell, natural
killer cell and dendritic cells to site of infection, dendritic cells process antigen and
present antigen to MHC I and MHC II proteins
what do CD8 cells with a TCR that recognizes M. tuberulosis antigen do? - Answer lyse
infected macrophages and dendritic cells, release IFn gamma which activated
macrophages
what do CD4 cells with a TCR that recognizes M. tuberulosis antigen do? - Answer
differentiate into Th2 and Th1 cells, Th1 release IFN gamma which activates
macrophages, Th1 release IL-2 and TNF alpha which recruit more T-cells, macrophages
and dendritic cells to site of infection
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Flat. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $8.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
79978 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now