OST 575 - Exam #3 Questions And Correct Answers --> Hepatobiliary disorders I
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Course
OST 575
Institution
OST 575
OST 575 - Exam #3 Questions And Correct
Answers --> Hepatobiliary disorders I
What is the process of cirrhosis? - answerinflammatory cells damage parenchyma-->
parenchyma begins to collapse-->
new collagen laid down, leads to scarring-->
scar will bridge portal regions and central ...
OST 575 - Exam #3 Questions And Correct
Answers --> Hepatobiliary disorders I
What is the process of cirrhosis? - answer✔inflammatory cells damage parenchyma-->
parenchyma begins to collapse-->
new collagen laid down, leads to scarring-->
scar will bridge portal regions and central vein regions *leading to fibrosis/cirrhosis*
What is the gross anatomy of someone with liver cirrhosis? - answer✔liver is smaller in weight
distinct nodules are usually present
texture is very firm
yellow-green discoloration
What cells in the liver start the cascade of release of various cytokines to cause damage? -
answer✔Kupffer cells
What cells become activated in response to hepatic injury and inflammation, leading to their
phenotypic changes allowing for collagen production and production of inhibitors of matrix
metalloproteinases to fill space of Disse? - answer✔Stellate cells
What are the patterns of hepatic injury? - answer✔Triaditis
Hepatitis
Cholangitis (cholestatic pattern)
Necrosis
What is Triaditis? - answer✔Inflammation filling and expanding the portal triad region
What is Hepatitis? - answer✔inflammation that surrounds and induces necrosis or apoptosis in
*hepatocytes*
Sometimes described as lobular inflammation
What is the formation of the lobular model of the liver? - answer✔central vein at center
Hepatocytes throughout lobule
multiple portal tracts around lobular periphery
Inflammation that surrounds and induces necrosis or apoptosis in *hepatocytes* is what type of
hepatic injury? - answer✔Hepatitis
What is Cholangitis? - answer✔inflammation in and around *bile ducts*
Can be caused by cholestasis or large accumulations of bile
Inflammation in and around the *bile ducts* that can be caused by cholestasis or large
accumulations of bile is what type of hepatic injury? - answer✔Cholangitis
What is necrosis of liver? - answer✔hepatocyte cell death in a large obvious manner due to
injury capable of killing hepatocytes
What is often the first visible pattern of injury in the liver? - answer✔Steatosis
What is steatosis? - answer✔collection of lipid material inside the hepatocytes
What laboratory values are used to assess hepatocyte synthetic function? - answer✔Albumin
coagulation factors
ammonia
What laboratory values are used to assess hepatocyte integrity/structure? - answer✔Aspartate
aminotransferase (AST)
alanine aminotransferase (ALT)
Lactate dehydrogenase (LDH)
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