OST 575 - Exam #3 Questions And Correct Answers --> Hepatobiliary Disorders II
0 view 0 purchase
Course
OST 575
Institution
OST 575
OST 575 - Exam #3 Questions And Correct
Answers --> Hepatobiliary Disorders II
What is the blood supply of the liver? - answer*dual blood supply* from hepatic artery and
portal vein
What is the common reaction pattern that occurs when the biliary system undergoes dysfunction
for any reason,...
OST 575 - Exam #3 Questions And Correct
Answers --> Hepatobiliary Disorders II
What is the blood supply of the liver? - answer✔*dual blood supply* from hepatic artery and
portal vein
What is the common reaction pattern that occurs when the biliary system undergoes dysfunction
for any reason, causing buildup of bile and bile pigments? - answer✔cholestasis
What are some mechanisms that can cause cholestasis? - answer✔decreased or defective bile
secretion
obstruction of bile channels, either intrahepatic or extrahepatic
What are symptoms of cholestasis? - answer✔jaundice
pruritis
malabsorption (particularly fat soluble vitamins)
What is the pathogenesis of cholestasis? - answer✔canaliculi expand with accumulate bile-->
excess bile/bile pigments will collect within and expand hepatocytes--> hepatocytes undergo
apoptosis
Microscopically, cholestasis will be evident early on as what? - answer✔green-brown-gold plugs
of bile within bile canalicular, hepatocytes, and Kupffer cells
Longer standing cholestasis can develop what as bile accumulates and this will cause the ductal
cells to do what? - answer✔develop bile plugs that will incite ductal cells to undergo
*hyperplasia* and create more of itself
What is the term for large stones/lithiases in the large extra hepatic bile ducts? -
answer✔choledocholithiasis
What can be a malignant obstruction of the common bile duct? - answer✔cholangiocarcinoma of
the large extra hepatic ducts OR
What is the term for the autoimmune large duct obstructive process? - answer✔primary
slcerosing cholangitis
How does ascending cholangitis occur? - answer✔when bacterial overgrowth complicates the
obstruction, with the somewhat stopped luminal fluid allowing for abundant bacterial growth
What can ascending cholangitis evolve further into? - answer✔suppurative cholangitis (extensive
pus)--> liver abscess or small bile induced necrosis
What becomes a big problem once suppuration from ascending cholangitis occurs? -
answer✔SEPSIS
What can happen with chronic bile duct obstruction? - answer✔on-going upstream
inflammation--> bile duct hyperplasia and ductal luminal expansion--> biliary induced cirrhosis
What is the most common cause of neonatal jaundice and cholestasis? - answer✔Biliary atresia
What is biliary atresia? - answer✔when there is partial or complete biliary obstruction at any
level or location of the biliary tree
How can biliary atresia occur? - answer✔if biliary tree didn't develop correctly in-utero
OR
normal biliary tree for some unknown reason undergoes destruction during infancy
What is the most frequent cause of liver transplantation in the neonatal period? - answer✔Biliary
atresia
What can biliary atresia affect? - answer✔intrahepatic or extrahepatic ducts
When is surgical correction possible for biliary atresia? - answer✔ONLY if it is *extrahepatic
obstruction*
What is the surgical procedure for biliary atresia that takes a portion of neonates small intestine
and sews it to the liver to act as a conduit for biliary system? - answer✔Kasai procedure
Who does autoimmune hepatitis commonly affect? - answer✔WOMEN
northern european ancestry
*those with HLA-DRB1 alleles*
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller sirjoel. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.49. You're not tied to anything after your purchase.
