OST 575 - Exam #3 Questions And Correct Answers --> Hepatobiliary Disorders II
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Course
OST 575
Institution
OST 575
OST 575 - Exam #3 Questions And Correct
Answers --> Hepatobiliary Disorders II
What is the blood supply of the liver? - answer*dual blood supply* from hepatic artery and
portal vein
What is the common reaction pattern that occurs when the biliary system undergoes dysfunction
for any reason,...
OST 575 - Exam #3 Questions And Correct
Answers --> Hepatobiliary Disorders II
What is the blood supply of the liver? - answer✔*dual blood supply* from hepatic artery and
portal vein
What is the common reaction pattern that occurs when the biliary system undergoes dysfunction
for any reason, causing buildup of bile and bile pigments? - answer✔cholestasis
What are some mechanisms that can cause cholestasis? - answer✔decreased or defective bile
secretion
obstruction of bile channels, either intrahepatic or extrahepatic
What are symptoms of cholestasis? - answer✔jaundice
pruritis
malabsorption (particularly fat soluble vitamins)
What is the pathogenesis of cholestasis? - answer✔canaliculi expand with accumulate bile-->
excess bile/bile pigments will collect within and expand hepatocytes--> hepatocytes undergo
apoptosis
Microscopically, cholestasis will be evident early on as what? - answer✔green-brown-gold plugs
of bile within bile canalicular, hepatocytes, and Kupffer cells
Longer standing cholestasis can develop what as bile accumulates and this will cause the ductal
cells to do what? - answer✔develop bile plugs that will incite ductal cells to undergo
*hyperplasia* and create more of itself
What is the term for large stones/lithiases in the large extra hepatic bile ducts? -
answer✔choledocholithiasis
What can be a malignant obstruction of the common bile duct? - answer✔cholangiocarcinoma of
the large extra hepatic ducts OR
What is the term for the autoimmune large duct obstructive process? - answer✔primary
slcerosing cholangitis
How does ascending cholangitis occur? - answer✔when bacterial overgrowth complicates the
obstruction, with the somewhat stopped luminal fluid allowing for abundant bacterial growth
What can ascending cholangitis evolve further into? - answer✔suppurative cholangitis (extensive
pus)--> liver abscess or small bile induced necrosis
What becomes a big problem once suppuration from ascending cholangitis occurs? -
answer✔SEPSIS
What can happen with chronic bile duct obstruction? - answer✔on-going upstream
inflammation--> bile duct hyperplasia and ductal luminal expansion--> biliary induced cirrhosis
What is the most common cause of neonatal jaundice and cholestasis? - answer✔Biliary atresia
What is biliary atresia? - answer✔when there is partial or complete biliary obstruction at any
level or location of the biliary tree
How can biliary atresia occur? - answer✔if biliary tree didn't develop correctly in-utero
OR
normal biliary tree for some unknown reason undergoes destruction during infancy
What is the most frequent cause of liver transplantation in the neonatal period? - answer✔Biliary
atresia
What can biliary atresia affect? - answer✔intrahepatic or extrahepatic ducts
When is surgical correction possible for biliary atresia? - answer✔ONLY if it is *extrahepatic
obstruction*
What is the surgical procedure for biliary atresia that takes a portion of neonates small intestine
and sews it to the liver to act as a conduit for biliary system? - answer✔Kasai procedure
Who does autoimmune hepatitis commonly affect? - answer✔WOMEN
northern european ancestry
*those with HLA-DRB1 alleles*
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