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BIOCHEM Midterm Exam 2 Questions with Verified Answers| 100% Correct| 100% Score
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BIOCHEM Midterm Exam 2 Questions with Verified Answers| 100% Correct| 100% Score
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BIOCHEM Midterm Exam 2 Questions with VerifiedAnswers| 100% Correct| 100% Score
You have identified a mutation in the c subunit in the ATP synthase. The mutation changes the
glutamate residue, (that facilitates proton pumping into the mitochondrial matrix), to a glycine. The
inability to dissipate the proton gradient will have which of the following impacts on the electron
transport chain? - ✔✔decrease ATP synthesis
During an overnight fast, which of the following pathways is the primary source of glucose required
for the maintenance of blood glucose levels? - ✔✔liver glycogenolysis
Retenone is an inhibitor of complex 1 in the electron transport chain. Which of the following will
not occur as a result of the addition of rotenone? - ✔✔Decrease Oxidation of FADH2
NOT: Decreased production of ATP - Decreased oxygen consumption - Decreased oxidation of NADH
In the liver, the pyruvate dehydrogenase complex (PDC) would be dephosphorylated and active
when which of the following compounds or hormones is elevated? - ✔✔glucagon
Glycogen synthesis and degradation in the liver and muscle is very similar. Which of the following
enzymes is not used in both muscle and liver for those metabolic pathways? - ✔✔hexokinase- glucose
6-phosphate
The primary GLUT transporter used by the liver is ____________ and the primary GLUT transporter used
by the skeletal muscle is ___________: - ✔✔GLUT2, GLUT4
Glucagon will influence the metabolism in the liver, adipose, and skeletal muscle during fasting. Which
of the following is consistent with the impact of glycogen? - ✔✔Glucagon will increase output of glucose
by the liver
,Insulin is a major metabolic hormone. Its primary role on metabolism is best summarized by which
of the following statements? - ✔✔It promotes fuel storage and growth after a meal
Certain conditions such as excessive alcohol consumption can increase the ratio of NADH/NAD+ in the
mitochondria. This will directly inhibit which of the following enzymes? - ✔✔PDC
The oxidation of glucose produces NADH. NADH can be oxidized in the mitochondria and in this process
the terminal electron acceptor in the electron transport chain is which of the following compounds? -
✔✔O2
Several TCA cycle intermediates can be used as a substrate for the synthesis of other compounds.
Succinyl CoA is an intermediate that is directly used for the synthesis of which of the following
compounds? - ✔✔heme
Dinitrophenol is an uncoupler of the electron transport cahin. The addition of dinitrophenol will
have which of the following impacts to the cell? - ✔✔increase oxygen consumption
Under conditions when a cell only needs to use the nonoxidative portion of the pentose phosphate
pathway to synthesize ribose 5-phosphate, the elevated levels of NADPH in the cell will inhibit which of
the following enzymes? - ✔✔G-6 phosphate dehydrogenase
When glucagon binds its receptor there is an increase in the second messenger, cAMP. cAMP levels can
be decreased by which of the following enzymes? - ✔✔phosphodiesterase
Which of the following tissues can use glucose, but not fatty acids, as a source of fuel? - ✔✔red
blood cells and the brain
Which of the following hormones binds to a receptor tyrosine kinase? - ✔✔insulin
Which of the following is true regarding single point mutations to a genomic DNA sequence? - ✔✔Single
nucleotide changes to the DNA sequence may have no impact on the primary sequence of a protein
, Prokaryotic genes are organized which contain a series of genes that are regulated by a common
promoter. In the case of an inducible operon, the operaon is transcribed: - ✔✔When the inducer
is bound to the repressor
Insulin is a peptide hormone secreted by the beta cells of the pancreas in response to elevated levels of
blood glucose. Locally, insulin will inhibit the release of glucagon from alpha cells in the pancreas, and it
will also impact the metabolism of many peripheral tissues. The actions of insulin are best described as
which of the following? - ✔✔Paracrine and endocrine
Based on the following schematic, which statement best describes the acid/base properties of guanine?
- ✔✔At physiological pH, guanine will be neutral
Following a meal, fructose 2,6 bisphosphate levels will be elevated in the liver. Under these conditions
which of the following will be dephosphorylated and inactive? - ✔✔glycogen synthase
All of the following are part of the Cori Cycle EXCEPT: - ✔✔ATP is produced by the conversion of
lactate to glucose
Which of the following is a monosaccharide? - ✔✔galactose
Which of the following compounds or hormones will not facilitate the process of skeletal
muscle glycogenolysis? - ✔✔Ca++
Chronic smokers have an elevation of guanine residues associated with a benzopyrene ring. This bulky
distoration to the DNA is repaired through which of the following mechanisms? - ✔✔nucleotide
excision repair
Under conditions of anaerobic glycolysis pyruvate is primarily oxidized to which compound: - ✔✔lactate
A 2-year-old boy is recently diagnosed with red-green color blindness which is an X-linked recessive
disorder. Which of the following represents the genotype of this individual? - ✔✔X'Y' (X' recessive
X allele and Y chromosome)
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