WEEK 8 NR 546 ACTUAL EXAM COMPLETE 33
QUESTIONS AND CORRECT DETAILED ANSWERS
(VERIFIED ANSWERS) |ALREADY GRADED
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Cholinesterase Inhibitors (ChEIs)X ✔✔CORRECT ANSWER✔✔do not
change the progression of AD
provide some alleviation of symptoms
eg. donepezil (Aricept), rivastigmine (Exelon), galantamine (Razadyne,
Razadyne ER),
donepezil (Aricept)
Mechanism of Action ✔✔CORRECT ANSWER✔✔inhibits centrally active
acetylcholinesterase
donepezil (Aricept)
Common Side Effects ✔✔CORRECT ANSWER✔✔gastrointestinal
symptoms (nausea and diarrhea)
headache
dizziness
muscle weakness
donepezil (Aricept)
Prescribing Pearls ✔✔CORRECT ANSWER✔✔Taper to avoid withdrawal
effects.
Donepezil (Aricept) is approved to treat moderate to severe AD at 23
mg/day dose, but there is minimal improvement in cognitive
functioning when compared to a 10 mg/day dose. At the higher dose,
donepezil has a higher incidence of adverse effects.
When Donepezil (Aricept) is added to CYP2D6 or CYP3A4, there is a
possibility of peripheral side effects, and inducers of CYP2D6 and
CYP3A4 may increase the rate of elimination
rivastigmine (Exelon)
Mechanism of Action ✔✔CORRECT ANSWER✔✔acts centrally for both
acetylcholinesterase and butyrylcholinesterase, thereby potentially
increasing its efficacy.
rivastigmine (Exelon)
Common Side Effects ✔✔CORRECT ANSWER✔✔Common Side Effects
gastrointestinal symptoms (anorexia, nausea, vomiting, or diarrhea)
weakness
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