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Ultimate psychopharm principles Exam Questions and Answers Graded A+ D2 blockade - Answers Common mechanism to all antipsychotics 65% - Answers D2 blockade for antipsychotic effect (% occupancy) 78% - Answers D2 blockade for parkinsonism (% occupancy) Mesolimbic, mesocortical, nigrostriatal, tu...

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  • October 17, 2024
  • 6
  • 2024/2025
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Ultimate psychopharm principles Exam Questions and Answers Graded A+

D2 blockade - Answers Common mechanism to all antipsychotics

65% - Answers D2 blockade for antipsychotic effect (% occupancy)

78% - Answers D2 blockade for parkinsonism (% occupancy)

Mesolimbic, mesocortical, nigrostriatal, tuberoinfundibular - Answers 4 dopamine pathways

Mesolimbic - Answers Pathway involved in positive symptoms

Mesocortical - Answers Pathway involved in negative symptoms

Low - Answers Low/high dopamine in mesocortical pathway in schizophrenia

Excess of Ach vs dopamine= EPS - Answers Effect of D2 blockade on nigrostriatal pathway

Hyperprolactinemia (dopamine inhibits prolactin) - Answers Effect of D2 blockade on tuberoinfundibular
pathway

5HT-2A blockade, rapid dissociation from receptor, partial D2 agonism - Answers Theories of atypicality
of antipsychotics (3)

Increased dopamine in mesocortical, nigrostriatal and tuberoinfundibular - Answers Effect of 5HT-2A
blockade (theoretical)

Partial D2 agonism, partial 5HT-1A agonism, 5HT-2A blockade - Answers Mechanism of aripiprazole

VTA, SN - Answers Cell bodies for dopamine neurons located mainly

Raphe nucleus - Answers Cell bodies for serotonergic neurons located

Locus ceruleus - Answers Cell bodies for noradrenergic neurons located

Positive allosteric modulation, binding to ion channels activated by GABA, enhancing effect of GABA on
channel conductance , GABA-A receptor - Answers Exact mechanism of benzos

Doxepin - Answers Most anticholinergic TCA

Desipramine - Answers Least anticholinergic TCA

2D6, 1A2 (to lesser extent) - Answers Main CYP involved in TCA metabolism

Nortriptyline - Answers Active metabolite of amitriptyline

1A2 - Answers Enzyme (CYP) converting amitriptyline to active metabolite

TCAs - Answers Class of medication that inhibits antihypertensive effects of clonidine

, NE and dopamine reuptake inhibition and stimulation of release (mostly of dopamine) - Answers
Mechanism of amphetamine stimulants

3A4, 2D6 - Answers CYP involved in metabolism of aripiprazole

NE reuptake inhibition, possible increase in dopamine - Answers Mechanism of action of atomoxetine

2D6 - Answers CYP involved in metabolism of atomoxetine

3A4 (+ auto induction) - Answers CYP involved in metabolism of carbamazepine

3A4 and 2C19 - Answers CYP involved in metabolism of citalopram

1A2, 3A4, 2D6 - Answers CYP involved in metabolism of clozapine

NE reuptake inhibition, blocks dopamine transporter - Answers Mechanism of action of bupropion

Action on voltage-sensitive sodium channels and inhibition of glutamate release - Answers Mechanism
of action of carbamazepine

Alpha-2 agonist (post synaptic) - Answers Mechanism of action of clonidine

Blocks benzodiazepine receptor at GABA-A ligand-gated chloride channel complex (competitive
antagonism) - Answers Mechanism of action of flumazenil

Inh 2D6 - Answers CYP inhibited/induced by bupropion

Induces 3A4 (auto induction) - Answers CYP inhibited/induced by carbamazepine

Inh 2D6 and 3A4 - Answers CYP inhibited/induced by fluoxetine

Induces 3A4 - Answers CYP inhibited/induced by St-John's wort

Opioids, THC, GHB - Answers Substance of abuse with effect on GPCR receptors

Benzodiazepines, nicotine, alcohol - Answers Substance of abuse with effect on ion channels

Selective agonism of nicotinic acetylcholine receptor (these receptors are located on dopamine neurons
in the VTA and dopamine is released in the nucleus accumbens ) - Answers Mechanism of nicotine

Reexposure to the drug, stress, exposure to cues associated with drug - Answers Triggers for substance
relapse

5HT-2A agonism - Answers Mechanism of action LSD

NMDA antagonist - Answers Mechanism of action PCP

Presynaptic inhibition of GABA neurons by CB1 agonism, causing disinhibition of dopamine neurons -
Answers Mechanism of THC on dopamine

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