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SPMM Adverse Effects – Questions & Accurate Answers
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SPMM Adverse Effects – Questions & Accurate Answers
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SPMM Adverse Effects – Questions & Accurate AnswersRisk of fatal agranulocytosis with clozapine Right Ans - 1 in 5000
Risk of fatal PE with clozapine Right Ans - 1 in 4500
Risk of fatal cardiomypathy with clozapine Right Ans - 1 in 1300
Risk of NMS with antipsychotics Right Ans - 0.5-1%
Risk of Ebstein's abnormality with lithium in pregnancy Right Ans - 20 x
increase
Discontinuation rate in CATIE trial Right Ans - 74%
Discontinuation rate in CATIE trial - olanzapine Right Ans - 64%
Discontinuation rate in CATIE trial - perphenazine Right Ans - 75%
Discontinuation rate in CATIE trial - quetiapine Right Ans - 82%
Discontinuation rate in CATIE trial - risperidone Right Ans - 74%
Discontinuation rate in CATIE trial - ziprasidone Right Ans - 79%
Lipid monitoring in olanzapine and clozapine Right Ans - Every 3 months
for the first year
Serotonin receptor causing sexual dysfunction Right Ans - 5HT-2
Serotonin receptor causing obesity Right Ans - 5HT-2C
Mechanisms for weight gain in antipsychotics Right Ans - H1 antagonism
Hyperprolactinaemia
Increased serum leptin leading to leptin desensitisation
5HT-2C antagonism
Which serotonin receptor is useful for controlling neurological symptoms in
serotonin syndrome? Right Ans - 5HT-2a
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