Exam (elaborations)
Hematology Exam 4 Review
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Hematology Exam 4 Review
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Hematology Exam 4 Review1. Where care cgranulocytes cproduced?: cBone cmarrow
2. Provide cthe csequence cof cmaturation cfrom cstem ccell cto cmature
csegmented cneutrophil.: c1. cPluripotential cstem ccell
2. Progenitor ccells
3. Precursor ccell c(myeloblast, cpromyelocyte, cmyelocyte, cmetamyelocyte
cband)
4. Segmented cneutrophil
3. What cis cthe cstimulus cfor cgranulocytes?: cColony cstimulating cfactor
4. Cell care creleased cin cthe cbone cmarrow cafter chow cmany cdays cof
cmaturation?: c5 cdays
5. What cis cthe ccirculating cpool cand cwhat cis cit cused cfor?: cPeripheral
cblood; cit cis cwhat cthe cdifferential cis cobtained cfrom.
6. What cis cthe cmarginating cpool?: cCells clocated cadjacent cto cthe
cendothelial clining cof cthe cvessels; cmigrate cto ctissues cfirst
7. What cis cfirst cseen cin ca cpromyelocyte cand ccontains cmyeloperoxidase?:
cPrima- cry cgranules c(nonspecific)
8. What cis cfirst cseen cin ca cmyelocyte cand ccontains clysozomes?:
cSecondary cgranules c(specific)
9. Provide cthe cgranulocyte ckilling cprocess. cTell cwhat chappens cin ceach
cstep.: c1. cChemotaxis: cmove cto cbacteria
2. Opsonization: ccoat cbacteria
3. Phagocytosis: cneutrophil cengulfs cbacteria
4. Degranulation: cgranules cfuse cthen cdischarge
5. Oxidative cburst: cgenerates cH2O2
6. Killing: cuses cpotent coxidants
7. Inflammation: cdamages csurrounding carea
10.What cis cthe crelative cWBC ccount?: cPercentage cbased con ca ctotal cof c100
cWBC
11.What c is c the c absolute cWBC c count?: c Relative c percentage c x c WBC
1 c/
,ccount c (# c cells cin c1 cmicroliter)
12.What cis cneutrophilia cand cwhat care cthe ccasues?: c- cIncreased ccount
- Bacterial cinfections, cstress, cinflammation, cmalignant cdisorders
c(leukemia)
13.What cis cneutropenia cand cwhat care cthe ccauses?: c- cDecreased ccount
- Leukemia, cchemo, caplastic canemia, cinfection
14.What cis cthe cratio cof csegs cand clymphs cin cchildren?: cIt cis cinversed
c(less csegs cat cbirth, cmore clymphs)
- Birth: c30%
- 6 cmonths: c60%
- 4 cyears: c50%
- 6 cyears: c40%
- 8 cyears: c30%
2 c/
, 15.What care ca chigh cnumber cof ceosinophils cseen cin?: cAllergies, cparasitic
cinfec- ctions, csome cleukemias
16.What care ca chigh cnumber cof cbasophils cseen cin?: cCML cand cother
cmyeloprolif- cerative cdisorders
17.What care ca chigh cnumber cof cmonocytes cseen cin?: cLeukemias, cbacterial
cinfec- ctions, cand crickettsial cinfections
18.What ctype cof ccell cindicators care cseen cin cinfection, cpregnancy, cand
cburns?: c- cToxic cgranulation
- Dohle cbodies
- Vacuoles
19. Chediak-Higashi csyndrome
- What care cthe csymptoms?
- What care csome ccharacteristics?: c- cAlbinism, crecurrent cinfection
s
- Giant, cfused clysosome cgranules
- Can coccur cin cmost ccells cthat chave cgranules
- Granules care cdysfunctional
- Rare, cfatal cautosomal crecessive ccondition
20.What cis cchronic cgranulomatous cdisorder?: c- cRecurrent cinfections
- Inability cfor coxidative cburst
21.NitroBlue cTetrazolium cReduction ctest cis cused cfor cwhich cdisorder?:
cChronic cgranulomatous
22.What cis cMay-Hegglin canomaly?: c- cDohle cbody clike all
cincludsions cin ccytes cgranulo-
- Giant cplatelets
- Bleeding cissue
23.What cis cAlder-Reilly canomaly?: cInherited ccondition cthat s cwith
cpresent ccourse cgranules cin call cWBC c(function cnot caffected) cdark,
24.What cis cPelger-Huet canomaly?: cInherited cor cacquired where
ccondition ctrophils cwill cbe cbi-lobed, cbut cit cdoes cnot ccause cneu-
can cissue.
(seen cin cburns, cdrug creactions, cinfections, cand cmyeloproliferative
orders)cdis
25.Pseudo-Pelger-Huet canomaly cis cwhat ctype cof cdisorder?:
cMyeloproliferative
3 c/
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