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Final Exam #1 – HDFN Questions 100% Solved.
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Final Exam #1 – HDFN Questions 100% Solved. In 1939, _________________ and _____________________ postulated the immunization of a mother to paternal antigen carried on fetus/newborn's RBCs - answerLevine + Stetson Maternal antibodies can be stimulated by these 3 things... 1. prior __________...

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  • October 18, 2024
  • 18
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • final exam 1 hdfn questions 100 solved

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©SIRJOEL EXAM SOLUTIONS
10/11/2024 1:41 PM



Final Exam #1 – HDFN Questions 100%
Solved.


In 1939, _________________ and _____________________ postulated the immunization of a

mother to paternal antigen carried on fetus/newborn's RBCs - answer✔Levine + Stetson


Maternal antibodies can be stimulated by these 3 things...

1. prior ______________________

2. prior/current _____________________


3. occcassionally during the ___________ of ____________ trimester of pregnancy - answer✔1.

pregnancy

2. transfusion

3. second + third

________________________________ refers to an immune response to foreign/non-self

antigens from another human. Foreign RBCs with these antigens can generate corresponding

Abs. Can you give an example? - answer✔Alloimmunization / Ex: fetal RBCs leak (hemorrhage)

into maternal circulation

, ©SIRJOEL EXAM SOLUTIONS
10/11/2024 1:41 PM


T or F. Alloimmunization in HDFN is only due to anti-D. - answer✔F, can be due to anti-D and

even anti-K

HDFN due to anti-k causes supression of _______________________

______________________ (f.e.) as well as _____________________ (h) - answer✔fetal

erythropoiesis + hemolysis


T or F, both IgM and IgG are capable of causing HDFN. - answer✔F, only IgG has the potential

to cause HDFN; most cause mild to moderate disease


Common Antibodies in causing HDN? - answer✔anti-D, anti-D+C, anti-D+E, anti-C, anti-E,

anti-c, anti-e, anti-K


Rare Antibodies in causing HDN? - answer✔anti-Fya, anti-s, anti-S, anti-M, anti-N


These antibodies never cause HDN. - answer✔anti-Le^a, anti-Le^b, anti-I, anti-IH, anti-P1


T or F. Lewis antibodies can cause HDFN. - answer✔F, anti-Le a or b can never cause HDFN


HDFN - Pathogenesis


T or F. Exposure to fetal RBCs an alloimmunization occur.....early in pregnacny - answer✔F,

.....late in pregnancy and at delivery

HDFN - Pathogenesis

, ©SIRJOEL EXAM SOLUTIONS
10/11/2024 1:41 PM


T or F, fetus/newborn of the first pregnancy are often affected by HDFN - answer✔F, they are

rarely affected

HDFN - Pathogenesis

1. Fetal ___________ leak into the maternal ____________________ inducing a immune

response from the mother's _______ cells - answer✔RBCs + circulation + B


HDFN - Pathogenesis

2. Maternal ___________ cross the _______________ into the fetal ___________________ -

answer✔Abs + placenta + circulation


HDFN - Pathogenesis


3. Maternal Abs in the fetal circulation bind to stimulating __________ - answer✔Ag


HDFN - Pathogenesis

4. Maternal Ab-coated Fetal RBCs are destroyed by fetal ______________

_____________________ (s.m.) - answer✔spleen macrophages


HDFN - Pathogenesis

5. Destruction of maternal Ab-coated fetal RBCs by fetal spleen macrophages induces

__________________ (a) and the fetal ______________ (m) responds by increasing

_______________________ (e) - answer✔anemia + marrow + eryhropoiesis

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