Management of BMI >/=35 + cormorbidity ANS✔✔ Bariatric surgery
Management of BMI >/=40 ANS✔✔ Bariatric surgery
Co-morbidities ANS✔✔ T2DM
HTN
OSA and other respiratory disorders
NAFLD
OA
lipid abnormalities
gastrointestinal disorders
heart disease
Medication assessment ANS✔✔ Every month x3 months, then every 3 months
Effective weight loss % ANS✔✔ >/=5% in 3 months
Avoid these wt loss meds with HTN/HD ANS✔✔ Sympathomimetics (phentermine/diethylproprion)
, Solution 2024/2025
Pepper
Avoid these wt loss medications with CVD ANS✔✔ Sypathomimetics
T2DM treatment + medications to support weight loss ANS✔✔ GLP-1 analog (mitigates associated weight gain due to
insulin) or SGLT-2 inhibitors + metformin. If using insulin, recommend basal instead of combo
Drugs that induce weight gain ANS✔✔ Tricyclic antidepressants (Amitriptyline)
oral contraceptives (Ortho Tri-Cyclen, Yaz)
antipsychotics (Risperidone)
anticonvulsants
glucocorticoids (cortisol)
sulfonyureas- ( Glimepiride, Glipizide)
glitazones (Actos)
B-blockers (Propranolol, Metoprolol, Atenolol)
Hormonal signals for appetite ANS✔✔ CCK- duodenum
K cells- duodenum and jejunum: gatric inhibitory polypeptide
PYY- ileum and colon
GLP-1 -ileum
Pancreas- Insulin
Adipose tissue: Leptin
Liver- glucagon
GLP-1 ANS✔✔ Secreted in response to glucose and promotes insulin release from pancreas and satiety
, Solution 2024/2025
Pepper
Ghrelin ANS✔✔ produced in the stomach, orexigenic
Leptin ANS✔✔ proportional to fat mass, anorexigenic
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