Exam #2 Patho part 1 (Rheumatoid psoriatic arthritis) Questions and Answers
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Course
Psoriasis
Institution
Psoriasis
rheumatoid arthritis (RA) - Answer--chronic systemic disease
-inflammation of connective tissue in the diarthrodinal (synovial joint)
-attacks more than just joints
-generalized aching and stiffness
-periods of remissions and exacerbation
rheumatoid arthritis (RA) extraarticular manife...
Exam #2 Patho part 1 (Rheumatoid
psoriatic arthritis) Questions and
Answers
rheumatoid arthritis (RA) - Answer--chronic systemic disease
-inflammation of connective tissue in the diarthrodinal (synovial joint)
-attacks more than just joints
-generalized aching and stiffness
-periods of remissions and exacerbation
Criteria for Rheumatoid Arthritis (RA) - Answer--Morning stiffness at least 1 hour for
Atleast 6 weeks
-Swelling of three or more joints for Atleast 6 weeks
-Swelling of wrist, metacarpophalangeal or proximal Interphalangeal joints for 6 or more
weeks
-systemic joint swelling
-Hand X ray changes typical of RA
-Rheumatoid nodules
-Serum rheumatoid factor
Results of Progressive Joint Destruction - Answer--May lead to subluxation (dislocation
of the joint resulting in misalignment of the bone ends)
-Instability of the joint
-Limitation of movement
Etiology of RA - Answer-Cause unknown
Pathophysiology of RA - Answer-Autoimmune
-Antigen/abnormal immunoglobulin G (IgG)
-Presence of autoantibodies (Rheumatoid factor)
, -Inflammation results in Pannus (granulation tissue at the joint margins) leads to
articular cartilage destruction
Genetic
-Predisposition/familial occurrence of "human leukocyte antigen (HLA) in Caucasian RA
patients
Criteria of Osteoarthritis - Answer--C/O palatable bony joint enlargement
-Morning stiffness (lasting <30 mins)
-pain
-common in older people
Physical exam results in osteoarthritis shows - Answer--Reduced range of motion
-Joint mal alignment
-Crepitus
Osteoarthritis tests ( Radiologic) - Answer--Presence of osteophytes
-Joint space narrowing
RA radiological findings - Answer--erosions on x ray or mri
-synovitis noted by ultrasound or MRI
RA serology findings - Answer--ESR or C reactive protein
-Anti CCP
Rheumatoid factor
Stage 1 of RA - Answer-Early
-non destructive changes on X-RAY
-possible osteoporosis
Stage 2 of RA - Answer-Moderate
-X-ray osteoporosis
-no joint d deformities
-possible pretense of extra articular soft tissue lesions
Stage 3 or RA - Answer-Severe
-X-ray evidence of cartilage and bone destruction
-osteoporosis
-joint deformity
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