chronic inflammatory infiltration of alveolar walls by cells
Fluid
Connective tissue
If ILD is left untreated, the inflammatory process can progress to what?
irreversible pulmonary fibrosis
(Note: scar tissue of lungs, lungs can't expand even on vent)
Anatomic Alterations of the Lungs (changes)
- Destruction of the alveoli and adjacent pulmonary capillaries
- fibrotic thickening of the respiratory bronchioles, alveolar ducts, and alveoli
- Granulomas
- Honeycombing and cavity formation
- fibrocalcific pleural plaques (asbestosis)
- Bronchospams
,- excessive bronchial secretion (caused by inflammation of airways ↑ in WBC )
IDL are grouped according to their?
- Occupational or environmental exposure
- disease associations
- specific pathology
Inorganic
not consisting of or deriving from living matter.
Organic
of, relating to, or derived from living matter
Inorganic exposures
- Asbestosis
- coal dust
- silica
- beryllium
- aluminum
- barium
- Clay
- iron
- certain talas
Organic Exposures causing ILD
- Hypersensitivity pneumonitis
- moldy hay
, - silage
- moldy sugar cane
- mushroom compost
- barley
- cheese
- wood pulp, bark, dust
- cork dust
- bird droppings
- paints
Occupation/environmental ILDs: Medication and illicit drugs
• Medication and illicit drugs (Note: all can cause other health problems)
-Antibiotics
- Anti inflammatory agents
- cardiovascular agents
- chemotherapeutic agents
- drug-induced systemic lupus erythematosus
- Illicit drugs
• radiation therapy
• irritant gases
Systemic Diseases
• Connective tissue diseases
- scleroderma
- rheumatoid arthritis
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