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OST 575 Exam Lower GI pharmacology |Questions with 100% Correct Answers
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OST 575 Exam Lower GI pharmacology |Questions with 100% Correct Answers
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OST 575 Exam Lower GI pharmacology|Questions with 100% Correct Answers
What are some drugs that can cause diarrhea? - ✔️✔️Anti-microbial's (broad spectrum like
tetracycline)
CHolinergic agonists and cholinesterase inhibitors
*Metoclopramide*
What does a Cathartic do? Laxative? - ✔️✔️Cathartic = produces prompt, fluid evacuation
laxative = produces soft, formed stool over longer period of time
What laxatives cause watery stool in 2-6 hrs? - ✔️✔️Magnesium laxatives
*castor oil*
PEG
What laxatives are pro kinetic ones (act primarily on motility)? - ✔️✔️5-HT4 receptor agonists
Opioid receptor antagonists
What laxatives are non specific stimulants (effects on fluid secretion and motility)? -
✔️✔️Bisacodyl
Anthraquinones (senna and cascara)
Castor oil
What laxatives are luminally active? - ✔️✔️Psyllium
Osmotic agents (nonabsorbable sugars)
Surfacants and emollients
Chloride channel activator (lubiprostone)
, Prolonged used of stimulate laxatives may cause what? - ✔️✔️IBS
Bulk forming laxatives should not be used in what type of patients? - ✔️✔️patients with
dysphagia or stenosis
What is the MOA of Lubiprostone (Amitiza)? - ✔️✔️Prostanoic acid derivative which stimulates
type 2 chloride channel in small intestine
*increases intestinal motility and decreases transit time*
How long does it take for Lubiprostone (Amitiza) to cause a bowel movement? - ✔️✔️>50% of
patients will have bowel movement WITHIN 24 HRS
What is Lubiprostone (Amitiza) approved for treatment of? - ✔️✔️idiopathic chronic constipation
IBS with constipation
What is the MOA of Linaclotide (Linzess)? - ✔️✔️guanylate cyclase C receptor agonist
*acts on luminal surface of intestinal epithelium to increase cGMP and activate CTFR ion
channel*
What are the adverse effects of Linaclotide (Linzess)? - ✔️✔️diarrhea
pain
flatulence
What is Linaclotide (Linzess) approved for treatment of? - ✔️✔️idiopathic chronic constipation
IBS with constipation
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