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APHON PRINCIPLES OF CHEMO AND BIOTHERAPY EXAM
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APHON PRINCIPLES OF CHEMO AND BIOTHERAPY EXAM
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APHON PRINCIPLES OF CHEMO ANDBIOTHERAPY 2024-2025 EXAM
What chemo agent interferes with protein synthesis? -
<<Answers>>>Hormonal agents
What chemo agents interfere with development of blood
vessels? - <<Answers>>>Angiogenesis inhibitors
What chemo classification provide an anti cancer effect and
not clearly understood? - <<Answers>>>Biological response
modifiers
What are common side effects of antitumor antibiotics? -
<<Answers>>>Bone marrow suppression, mucositis, N&V,
cardiac toxicity, reproductive disabilities
Which antitumor antibiotic is cell cycle specific? -
<<Answers>>>Bleomycin-it works in both G2 and M phase
What are the major side effects of antimetabolites? -
<<Answers>>>Bone marrow suppression, N&V, mucositis,
liver injury
What pediatric chemo drugs are antimetabolite agents? -
<<Answers>>>Methotrexate, fluorouracil (5-FU), cytarabine
(Ara-C),
, APHON PRINCIPLES OF CHEMO AND
BIOTHERAPY 2024-2025 EXAM
Mercaptopurine (6-MP), thioguanine (6-TG), hydroxyurea
Which antimetabolite is associated with hepatoportal sclerosis
and esophageal varices? - <<Answers>>>Thioguanine
Which chemotherapy agents are hormonal agents? -
<<Answers>>>Corticosteroids
How do corticosteroids fight cancers? - <<Answers>>>By
lysing lymphoblasts, decreasing cerebral edema associated
with brain tumors, and help with antiemetic control
What are side effects of corticosteroids? -
<<Answers>>>Increased appetite, redistribution of body fat,
hyperglycemia, acne, striae, behavior changes, avascular
necrosis.
Is asparaginase cell cycle specific or nonspecific? -
<<Answers>>>Nonspecific
What class of drug are interferons? -
<<Answers>>>Biotherapy or biological response modifiers
(BRM)
Which agents are Cell Cycle Specific? -
<<Answers>>>Antimetabolites, plant alkaloids, and misc
agents such as asparaginase and dacarbazine.
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