Hematology Final Exam Question and Answers [100% Correct] 2024/2025 Latest Release!!
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Course
Hematology
Institution
Hematology
Hematology Final Exam Question and
Answers [100% Correct] 2024/2025
Latest Release!!
What is the primary function of erythropoietin in hematopoiesis?
Erythropoietin stimulates red blood cell production in the bone marrow.
Describe the role of ferritin in the body’s iron metabolism. ...
Hematology Final Exam Question and
Answers [100% Correct] 2024/2025
Latest Release!!
What is the primary function of erythropoietin in hematopoiesis?
Erythropoietin stimulates red blood cell production in the bone marrow.
Describe the role of ferritin in the body’s iron metabolism.
Ferritin stores iron in cells and releases it when needed for processes like hemoglobin synthesis.
What is the consequence of a G6PD deficiency in red blood cells?
G6PD deficiency leads to oxidative stress in red blood cells, causing hemolysis.
How does vitamin B12 deficiency affect red blood cell formation?
Vitamin B12 deficiency impairs DNA synthesis, leading to megaloblastic anemia.
Explain the role of the spleen in hemolytic anemia.
The spleen removes damaged or abnormal red blood cells from circulation, contributing to
anemia.
Why does sickle cell anemia cause painful vaso-occlusive crises?
Sickle-shaped cells block small blood vessels, reducing oxygen delivery to tissues and causing
pain.
What are Howell-Jolly bodies, and what do they indicate about the spleen?
Howell-Jolly bodies are remnants of nuclear material in red blood cells, indicating asplenia or
splenic dysfunction.
How does thrombopoietin regulate platelet production?
1
, Thrombopoietin stimulates the production and maturation of megakaryocytes, leading to platelet
formation.
What laboratory findings are characteristic of iron-deficiency anemia?
Low hemoglobin, low mean corpuscular volume (MCV), low serum ferritin, and high total iron-
binding capacity (TIBC).
Explain the significance of the Philadelphia chromosome in chronic myeloid leukemia (CML).
The Philadelphia chromosome results from a translocation between chromosomes 9 and 22,
producing a BCR-ABL fusion gene that drives CML.
How does hepcidin regulate iron homeostasis in the body?
Hepcidin controls iron absorption by inhibiting ferroportin, the protein responsible for iron
transport out of cells.
What role does folate play in red blood cell development, and what happens in folate deficiency?
Folate is crucial for DNA synthesis; deficiency results in megaloblastic anemia.
Why does hemophilia A lead to prolonged bleeding?
Hemophilia A is caused by a deficiency in factor VIII, leading to impaired blood clotting.
How does a high reticulocyte count help differentiate between types of anemia?
A high reticulocyte count indicates increased red blood cell production, suggesting hemolytic or
blood-loss anemia.
What is the pathophysiology of hereditary spherocytosis?
A defect in red blood cell membrane proteins causes cells to become spherical, making them
more prone to destruction by the spleen.
What is the role of von Willebrand factor in the coagulation cascade?
2
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