, Solution 2024/2025
Pepper
- Predisposing factors (liver or kidney disease) - Drug allergies
- Advanced age
- Pregnant or nursing
- Labs and history are also important (ex: Coumadin/ warfarin)
Nursing Responsibility - Client Education
❖Drug name and therapeutic category
❖Dose and dose schedule
❖Route of administration and technique if needed
❖Expected therapeutic response
❖Duration of treatment
❖Storage of medication
❖Symptoms Adverse effects to monitor and who to notify if occur
❖Drug - Drug interactions or Drug-Food interactions
❖Non-drug measures that may enhance response
Pharmacokinetics
the study of drug movement throughout the body (absorption,
distribution, metabolism, excretion)
Pharmacodynamincs
what the drug does to the body
Mechanism of Action
Therapeutic range
Pharmacologic response is produced and adverse effects are prevented in
most patients
Movement of the drug from the site of administration to the blood (IV
administration no absorption as it bypasses and goes straight to blood)
Pharmacokinetics - Distribution
- "transporting" the drug molecule to its site of action from blood to tissue to
cells
- Determined by blood flow to tissues, ability of drug to exit the vascular
system and the ability of the drug to enter the cells.
Pharmacokinetics - Metabolism (biotransformation)
Chemical alteration of the drug structure so they can be excreted more
easily.
Pharmacokinetics - Elimination
Drug is eliminated or removed from the body (most commonly through liver
and kidney)
Pharmacokinetics - Clearance
Determined by blood flow to the organ that metabolizes (liver) or eliminates
(kidney) the drug AND the efficiency of the organ in extracting the drug
from the bloodstream
Pharmacokinetics - Half-life
- Time required for serum concentrations to decrease by one-half after
absorption and distribution are complete
- Determines time to reach steady state (4-5 Half-lives to reach steady
state)
Pharmacokinetics - Factors to consider when deciding best drug for
your client
Age
Gender
Weight
Disease states
Genetics
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