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15_Over view of Hematopoiesis Questions With Complete Solutions
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15_Over view of Hematopoiesis Questions With Complete Solutions
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15_Over view of Hematopoiesis Questions With CompleteSolutions
Are megakaryocytes usually present in the periphery? Correct
Answer Yes, they are usually present in the periphery.
At what stage does commitment to the granulocyte lineage
begin? Correct Answer CFU-GM (granulocyte/monocyte
colony forming unit) stage.
How are platelets cleared from circulation? Correct Answer
Platelets are cleared via macrophages in the reticuloendothelial
(RE) system.
How can the composition of blood be assessed? Correct Answer
The composition of blood can be assessed by centrifugation,
which separates blood components based on density.
How does anemia affect clinical correlation? Correct Answer
Clinical correlation is lower with anemia.
How does polycythemia affect clinical correlation? Correct
Answer Clinical correlation is higher with polycythemia.
How does TPO bind to megakaryocytes? Correct Answer TPO
binds to megakaryocytes via the c-MPL receptor.
How is the composition of circulating cells in peripheral blood
different from bone marrow? Correct Answer Circulating
blasts/early granulocytes should not be present, but a left shift is
, possible. Monocytes are present, and few/no nucleated red cells
are present.
How long do platelets circulate for? Correct Answer Platelets
circulate for 7-10 days.
How long do reticulocytes circulate in the blood? Correct
Answer Reticulocytes have been released from the marrow
within the last 24 hours.
How long is the lifespan of mature red blood cells? Correct
Answer The lifespan of mature red blood cells is approximately
120 days.
How many anucleate platelets does one megakaryocyte
produce? Correct Answer One megakaryocyte produces 2000-
3000 anucleate platelets.
What are examples of mediate differentiation? Correct Answer
M-CSF for monoblasts/monocytes and IL-5 for eosinophils.
What are hematopoietic growth factors? Correct Answer
Cytokines that influence survival, proliferation, and
differentiation of stem cells and progenitor cells.
What are lineage-specific markers? Correct Answer Markers
expressed by cells as they differentiate into specific lineages.
What are multilineage growth factors? Correct Answer Growth
factors that act early in hematopoiesis and are required for the
proliferation and differentiation of stem cells.
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