Potency - ✔✔✔ - Dose of drug required to produce given effect; 50% of maximal response the drug is
capable of producing
Efficiacy - ✔✔✔ - Maximal response a drug is capable of producing
Ka - ✔✔✔ - Volume needed to get one mole of an unbound drug when 50% of target receptors are
occupied. L/mole
Kd - ✔✔✔ - Concentration of drug in the plasma when 50% of the target receptors are occupied. Mole/L
Non-competitive (irreversible) antagonist LDR curve - ✔✔✔ - Moves to the right and down
Competitive (reversible) antagonist LDR curve - ✔✔✔ - Moves to the right and parallel
Synthesis of NE - ✔✔✔ - Occurs at adrenergic neuron; Tyrosine to DOPA to dopamine to NE. Binds to
alpha and beta receptors. Degraded by COMT and MAO.
Bethanechol - ✔✔✔ - Muscarinic agonist prototype. Selective, binds to M3 receptors in the bladder and
causes bladder muscle contraction and sphincter relaxation.
Indicated for urinary retention in postop or pp pts.
AEs: salivation, lacrimation, bronchospasm, diarrhea, and bradycardia
Antihypertensive: inhibits NE release by binding to presynaptic alpha 2 receptors, inhibits sympathetic
outflow in CNS (these are greater than vasoconstrictive effects)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller SMARTSCORE. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.99. You're not tied to anything after your purchase.
