10/24/24, 8:08 PM NRNP 6635 -SCHIZOPHRENIA FINAL EXAM | 2024-2025 UPDATE COMPREHENSIVE MOST FREQUENTLY TESTED QU…
NRNP 6635 -SCHIZOPHRENIA FINAL EXAM |
2024-2025 UPDATE COMPREHENSIVE MOST
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Terms in this set (32)
a psychological disorder characterized by
delusions, hallucinations, disorganized speech,
Schizophrenia
and/or diminished inappropriate emotional
expression.
The signs and symptoms of schizophrenia are
traditionally separated into 2 groups: positive
signs and symptoms of
(delusions, hallucinations, and disorganized speech
schizophrenia
or behavior) and negative (flat affect, avolition,
anhedonia, poor attention, and alogia).
a decline in both cognitive and social functioning
Schizophrenia is
that often precedes the development of florid
associated with
psychosis.
The exact etiology of schizophrenia is unknown,
although it is thought to be linked to an increase in
Etiology of Schizophrenia dopaminergic activity.
No single etiological factor is responsible for
schizophrenia.
Treatment of Treatment includes antipsychotics in conjunction
Schizophrenia with behavioral therapy.
Schizophrenia is a chronic serious mental disorder
characterized by loss of contact with reality and
Schizophrenia definition
manifested by two main symptoms: hallucinations
and delusions.
, 10/24/24, 8:08 PM NRNP 6635 -SCHIZOPHRENIA FINAL EXAM | 2024-2025 UPDATE COMPREHENSIVE MOST FREQUENTLY TESTED QU…
Men and women are equally affected, but with a
slight difference in the age of onsetMen: average
onset of schizophrenia
age of onset = 23 years Women: average age of
onset = 26 years
The disorder manifests when a person with a genetic
predisposition is exposed to one of many
Etiological factors of
environmental stressors.
schizophrenia
- genetic predisposition
- environmental stressors
Environmental stressors are believed to be triggers
of schizophrenia rather than true causes of the
disorder.
-Childhood trauma
- Residence in an urban area
Environmental Stressors - Social isolation
of Schizophrenia -Frequent cannabis use in early adolescence
- Migration
- Poverty
- Stress and psychosocial factors
- Birth in late winter or early spring
-Advanced paternal age at conception
Genetic and environmental risk factors appear to
act via a common pathway
of disrupting the function of 1 or more
neurotransmitter components.
Dopaminergic theory: Almost all drugs with
antipsychotic properties block the dopaminergic D2
receptor.
However, antipsychotics are only 70% effective and
Pathophysiology of
clozapine, the most effective antipsychotic for
schizophrenia part 1
treating schizophrenia, is a weak D2 antagonist.
Hyperactivity of dopamine D2 receptor
neurotransmission in subcortical, and limbic brain
regions contribute to the positive symptoms of
schizophrenia. Hypo functionality of dopamine D1
receptor neurotransmission in the prefrontal cortex
contributes to both negative and cognitive
symptoms.
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