TTC NUR 161 Test 2 Exam Study Guide.
Nonselective Beta-Adrenergic Blocking Agent (Alfa Beta Blocker)
(Propranolol) - Actions:
Competitively blocks receptors in heart
(= decreased HR contractility, excitability, membrane stabilization, decrease arrhyth.,
decrease heart workload, decrease O2 use) & in juxtaglomerular app. in nephron (no renin
released = further decrease in BP.
Indication:
*HTN, angina, migraine headaches
Re-infarction after MI's
Prevention of stage fright
Essential tremors
Nucleoside inhibitors
(Zidovudine) - Indication:
Combination HIV tx
Nucleoside inhibitors
(Zidovudine) - Action:
Competes w/naturally occurring nucleosides w/in cell that the virus needs to develop and
build DNA chain = No production *Can't build DNA chain!*
Nucleoside inhibitors
(Zidovudine) - Caution:
Hep/Renal dysfx
Bone marrow suppression
Contra:
No breast feeding!!
Nucleoside inhibitors
,(Zidovudine) - Drug-Drug:
Alcohol
Some HIV meds
Antibiotic/Anti-fungal (Increase their effects!)
Nucleoside inhibitors
(Zidovudine) - Nursing C's:
Safe if pregnant!
Reverse Transcriptase Inhibitors-non nucleoside
(Nevirapine, Abacavir, Viread) - Indications:
HIV/AIDs w/ARC w/ decreased # of helpter T cells and increased opportunistic infections
Reverse Transcriptase Inhibitors-non nucleoside
(Nevirapine, Abacavir, Viread) - Action:
Binds directly to HIV recerse transc. = Blocks RNA & DNA dependent DNA polymerase =
*virus can't form viral DNA* & can't take over cell/reproduce
Protease Inhibitor
(Fasamprenavir) - Actions:
BLocks protease activity w/in HIV virus = *remains immature & non-infective (unable to
fuse w/and inject ifself into cells)*
Indication:
Part of combo therapy for HIV inf.
Reverse Transcriptase Inhibitors-non nucleoside
(Nevirapine, Abacavir, Viread) - Caution:
Hepatic dysfx
**saquinavir safe for lact**
Contra:
No breast feeding!!
Rash = Steven Johnson syndrome
Use in children not est.
Reverse Transcriptase Inhibitors-non nucleoside
(Nevirapine, Abacavir, Viread) - Drug-Drug:
Ritonavir
Many other drugs
Nonsedating antihistamines
, Sedatives/Hypnotics
Antiarrhythmics
Reverse Transcriptase Inhibitors-non nucleoside
(Nevirapine, Abacavir, Viread) - Adverse:
Headache
Mood changes
Nausea
diarrhea
fatige
Rash may = Steven Johnson Syndrome*
Hump, thin arms/legs*
Reverse Transcriptase Inhibitors-non nucleoside
(Nevirapine, Abacavir, Viread) - Nursing C's:
Pt's on diabetic drugs may require dose adjustments*
Monitor renal/hep fx*
Stop is rash occurs!*
Reg med care, periodic blood tests*
Fusion Inhibitor
(Enfuvirtide) - Actions:
Prevents the fusion of the virus within human cellular memb. = virus can't enter. (Can't
Fuse!)*
Indications:
HIV inf...combo therapy
Adults & children over 6yrs
evidence of HIV rep. despite therapy
Fusion Inhibitor
(Enfuvirtide) - Pharmaco.:
SubQ inj.
Not excreted, recycled in the tissues**
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