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MICN201 Jefka228's Chem Path (Jaundice) Exam
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MICN201 Jefka228's Chem Path (Jaundice) Exam...
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MICN201 Jefka228's Chem Path (Jaundice) ExamJaundice: - Answer Yellow colour of skin and sclerae due to a rise in plasma bilirubin
concentrations
Temporary jaundice in prematurity:- Answer Due to an increase in unconjugated
bilirubin resulting from increased breakdown of foetal RBCs after birth and delayed
maturation of glucuronyl transferase - the enzyme which conjugates bilirubin
Haemolytic anaemia: - Answer Total bilirubin and unconjugated bilirubin increases,
conjugated bilirubin remains normal, urine urobilinogen increases and urine bilirubin is
absent
Cholestasis: - Answer Total bilirubin increases significantly, unconjugated bilirubin
increases or remains normal, conjugated bilirubin increases significantly, urine
urobilinogen decreases, urine bilirubin is present
Bile Pigments vs bile salts: - Answer Bile pigments are the coloured derivatives of haem
(bilirubin, urobilin, stercobilin), bile salts are made from cholesterol and are used in
digestion and absorption of lipids
Large increases in urinary urobilinogen: - Answer Haemolytic jaundice
Disappearances of urinary urobilinogen: - Answer Severe obstructive jaundice
Liver carbohydrate metabolism: - Answer Glycogen metabolism, gluconeogenesis,
pentose-P shunt
Liver lipid metabolism: - Answer Fatty acid and TAG synthesis, ketone body synthesis,
phospholipid and cholesterol metabolism
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