Maryville University Pharmacology NURS 615 Exam 2 Questions and Answers (100% Pass) 2024 What blood values should be monitored with carbamazepine (Tegretol)?
P. 236-237
Answer CBC for agranulosytosis (leukopenia/ neutropenia), BMP, and liver function
tests, monitored at baseline prior to adminis...
Maryville University Nurs 615 Pharm Exam 2.pdf file:///C:/Users/HP/Desktop/New%20folder%20(4)/Maryville%20Univ
Maryville University Pharm Exam 2
Questions & Answers
1. What blood values should be monitored with carbamazepine (Tegretol)?
P. 236-237
Answer CBC for agranulosytosis (leukopenia/ neutropenia), BMP, and liver function
tests, monitored at baseline prior to administration and followed throughout
treatment
2. What is the pharmacodynamics of carbamazepine (Tegretol)? P. 235
Answer Carba-mazepine depresses transmission in the nucleus ventralis anterior of
the thalamus.This area is associated with the spread of seizure discharge. Exact
mechanism of action not known but may work by slowing sodium influx to the cortical
neurons thusslowing the spread of abnormal neuron activity.
3. What should families be taught regarding the monitoring of seizure ac-
tivity?
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,Maryville University Nurs 615 Pharm Exam 2.pdf file:///C:/Users/HP/Desktop/New%20folder%20(4)/Maryville%20Univ
Answer Seizure triggers, when to contact the physician, how to take medications
properly and that medication needs may change with patient growth (kids), need for
monitoring blood levels, signs of adverse drug reactions
4. What electrolyte imbalance is noted with the administration of topiramate
(Topamax)? P. 239
Answer Topiramate is a carbonic anhydrase inhibitor used for seizuresand migraines.
This can increase bicarb loss (via the kidneys) which decreases serum bicarb levels.
The result is hyperchloremic metabolic acidosis.
5. What is the pregnancy category for valproate?
Answer Pregnancy category D (FDAdropped Pregnancy category designations June
2015)
6. What instructions will you provide to a woman who wants to get pregnant
and has a seizure disorder controlled with valproate? P. 278-279
Answer She shouldbe advised to speak with her neurologist before trying to get
pregnant. Valproate isa known teratogen (it can lead to neural tube defects), but may
be taken after the first trimester if needed.
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7. What are the precautions and contraindications for the tricyclic antide-
pressants? P. 245-246
Answer Contraindicated with cardiovascular disorders (Direct alphaadrenergic
blocking effect and quinidine like effect on the myocardium). Use with caution in
those with glaucoma, prostatic hypertrophy, or urinary incontinence. Do not use in
combination with MAOIs. Two week washout period. Use with extreme caution in
pregnancy. Most significant risk is cardiac conduction disorder mostly inpeds and
elderly. May develop sinus tachycardia due to slowing of depolarization of the cardiac
muscle contributing to prolongation of the QRS complex and PR/QTinterval.Can
lower seizure threshold in those with seizure disorder.Use with extremecaution in the
elderly (norepinephrine effects in the elderly can result in confusion, orthostatic
hypotension, and falls. May develop tardive dyskinesia
8. Phenelzine (Nardil) is an MAO inhibitor.What are the cautions and con-
traindications? How is it used to treat recalcitrant depression? P. 248-249
Answer - Most commonly used for refractory unipolar depression. Irreversibly
inactivate the enzymes that metabolize norepinephrine, serotonin, and dopamine
which increases
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