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Turcan SBB exam review AABB Packet |Questions with Complete Solutions
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Turcan SBB exam review AABB Packet|Questions with Complete Solutions
No algorithm available for reentry by FDA for these - ✔HIV and HCV NAT pos tests
Components for correction of coagulopathies - ✔Plasma
PLTs
Cryo
Components for replacing deficient coag factors - ✔FFP
Cryo
Components for fighting infections - ✔WBCs
Use for cryo-poor plasma - ✔treat TTP patients
PLTs purpose and contraindication - ✔Improve
hemostasis do not give for TTP or ITP unless absolutely
necessary
Fathers genotype is BO, mom's is OO. Prob to have 3 OO kids? - ✔0.5x0.5x0.5 = .125
Calcium's involvement in coag cascade - ✔involved at:
,12a and 11 reaction to 11a
11a and 9 reaction to 9a
9a's and 8a's reaction on 10 to 10a
10a's and 5a's reaction on prothrombin to thrombin
Coag factor enzymes - ✔Factor 2a
Factor 7a
Factor 9a
Factor 10a
Protein C
TPA
Plasmin
Coag Factor Cofactors - ✔Tissue Factor
Factor 5
Factor 8
Protein S
Coag Factor Miscellaneous - ✔Fibrinogen
Factor 13
Alpha-2 antiplasmin
PAI-1
Antithrombin
Vit K dependent factors - ✔2
7
9
, 10
Protein C
Protein S
Cofactors 5 and 8 - ✔Require activation by
thrombin enhances efficiency of coag factors by
100,000 fold
Coagulation process - ✔Enzyme binds a cofactor which is bonded by calcium to a
surface Calc binds protein to surfaces
Enzyme and Cofactor binding examples - ✔VIIa and TF (cofactor)
IX and VIII (Cofactor)
X and V (Cofactor)
Formation of Fibrin clot - ✔Thrombin acts on
fibrinogen makes a fibrin monomer and FPA, FPB Fibrin
monomer becomes Fibrin polymer
Factor 13 acts on fibrin polymers to form
Fibrin clot
Contact System of Coag cascade - ✔12, Kallikrein (HK and PK)
Plays role in inflammation
deficiencies do not cause bleeding!!
Factor XI - ✔Deficiencies cause bleeding, especially after surgery
Fibrinolysis key proteins - ✔Plasminogen
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