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NSAIDS & Cyclooxygenase Inhibitors correctly answered to pass
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NSAIDS & Cyclooxygenase Inhibitors correctly answered to pass
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NSAIDS & Cyclooxygenase Inhibitorscorrectly answered to pass
Peripherally acting analgesics decrease pain without the loss of consciousness.
What are the two nervous systems these analgesics work on? - correct answer ✔✔PNS & CNS
What is the purpose of: Proteinoids, Bradykinin, ATP, Histamine, & Serotonin? - correct answer
✔✔Inflammatory mediators that stimulate afferent nociceptors
Draw & describe AA pathway. - correct answer ✔✔PP slide #3
What is the role of cyclooxygenase? - correct answer ✔✔Catalyze synthesis of prostaglandins from: AA,
PGH2 & COX1/2
What is required to produce prostacyclin and thromboxane? - correct answer ✔✔COX 1 & COX 2
COX 1 is responsible for: - correct answer ✔✔Gastric mucosa, renal parenchyma & platelets
COX 2 is responsible for: - correct answer ✔✔Mediates inflammation, pain, fever & carcinogenesis
COX 1 or COX 2:
Mediation of pain, inflammation & fever
Maintenance of normal renal function
Mucosal protection of GI tract
Production of TxA2 for platelet function - correct answer ✔✔COX 1
Define TxA2 - correct answer ✔✔Proaggregatore of platelets
COX 1 or COX 2:
, Mediation of pain, inflammation & fever
PGI2 (Prostacyclin) - correct answer ✔✔COX 2
Define PGI2 (Prostacyclin) - correct answer ✔✔Inhibitor of platelet aggregation
NOT important to humans
MAY contribute to MOA of Tylenol - correct answer ✔✔COX 3
What are the three effects of NSAIDS? - correct answer ✔✔Analgesic, antipyretic & anti-inflammatory
(high dose)
Traditional NSAIDS inhibit both? - correct answer ✔✔COX 1 & COX 2
Describe the MOA of NSAIDS. - correct answer ✔✔PP slide # 9
NSAIDS ADRS-Platelet Function
1) Plt aggregation is incduced through an increase in what?
2) NSAIDS & asprin inhibit the activity of? And COX 2 have NO effect on? - correct answer ✔✔1)
Thromboxane production following activation of COX 1
2) COX 1. COX 1 and no effect on platelet function.
NSAIDS ADRS-GI
1) NSAIDS are associated w/ lower or upper GI complications?
2) Name risk factors r/t NSAIDS.
3) Pts w/ risk factors should be prescribed what instead on NSAIDS? - correct answer ✔✔1) Upper
2) High dosage, old age, H. Pylori, prior ulcer & low-dose ASA w/ anticoagulants
3) COX 2 or non selective NSAIDS w/ GI protective therapy
NSAIDS ADRS-CV
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